Apparatus and method for glycopeptide analysis

A technology of glycopeptide and analysis system, which can be applied to analysis materials, parts of particle separator tubes, particle separation tubes, etc., and can solve problems such as unavailability of labels

Active Publication Date: 2020-03-06
DH TECH DEVMENT PTE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Since electron-based dissociation methods performed on intact glycopeptides preferentially dissociate peptide chains rather than glycan rings, glycopeptides themselves cannot utilize the identification of linkage sites (without pre-isolation of glycans from peptides by e.g. enzymatic cleavage)

Method used

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  • Apparatus and method for glycopeptide analysis
  • Apparatus and method for glycopeptide analysis
  • Apparatus and method for glycopeptide analysis

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Embodiment Construction

[0024]Those skilled in the art will understand that the systems and methods described herein are non-limiting exemplary embodiments and that the scope of Applicants' disclosure is defined only by the claims. While Applicants' teachings are described in connection with various embodiments, it is not intended that Applicants' teachings be limited to such embodiments. On the contrary, it should be appreciated by those skilled in the art that the applicant's teachings encompass numerous alternatives, modifications, and equivalents. Features illustrated or described in connection with one exemplary embodiment may be combined with features of other exemplary embodiments. Such modifications and variations are intended to be included within the scope of applicant's disclosure.

[0025] see now figure 1 , depicts an exemplary system 100 that depicts an embodiment of the present teachings. A sample 105 containing or suspected of containing one or more glycopeptides of the character ...

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Abstract

A system and method is described for characterizing glycopeptides which includes a first quadrupole mass filter, a multipole rod set of an ion guide, a lens electrode, an ExD device and a mass analyzer. The multipole rod set is adapted to receive a radial radio frequency (RF) trapping voltage and a radial dipole direct current (DC) voltage. The lens electrode is adapted to receive an axial trapping alternating current (AC) voltage and a DC voltage. The ExD device performs electron capture dissociation or electron transfer dissociation, the ExD device being positioned so that an entrance of theExD device is disposed on the other side of the lens electrode opposite the multipole rod set. The mass analyzer is positioned at an exit of the ExD device for receiving ions from the ExD device.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Application Serial No. 62 / 525,901, filed June 28, 2017, the contents of which are hereby incorporated by reference in their entirety. technical field [0003] The teachings described herein relate to glycopeptide analysis using mass spectrometry and devices and methods to achieve the same. Background technique [0004] Glycopeptides are a class of peptide structures that include one or more carbohydrate moieties covalently bonded to the side chains of the amino acid residues that make up the peptide. In several instances, glycans form the backbone of the sugar moiety. Glycopeptides are classified depending on the linkage between the glycan moiety (ie carbohydrate) and the amino acid residues. Additionally, linkages between glycan moieties are also important. [0005] Glycopeptides can be characterized in a constrained fashion using conventional mass spectrometry....

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/42G01N33/68
CPCH01J49/0072G01N33/6848H01J49/0054H01J49/4225H01J49/067H01J49/005H01J49/421H01J49/022
Inventor 马场崇Y·勒布朗
Owner DH TECH DEVMENT PTE
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