Standardized collection and sensing method of clinical expiration sample in non-invasive lung cancer screening

Abstract

The invention discloses a standardized collection and sensing method of a clinical expiration sample in non-invasive lung cancer screening. The method comprises the following steps of constructing a sensing chip, and constructing a self-calibration multi-parameter sensing device for quickly identifying lung cancer; sampling the expiration; sensing and recognizing an expiration sample; connecting agas bag with the sensor to enable the gas and a photosensitive material above the sensing chip to generate the cross response and enable the color and the RGB value of the photosensitive material tobe changed; and collecting a difference spectrum image and a 30-dimensional RGB value before and after the reaction of a calibration sensing chip and a measurement sensing chip for the further analysis and judgment. The standardized collection and sensing method of the clinical expiration sample in non-invasive lung cancer screening solves the field calibration problem in the rapid lung cancer recognition by using a dual-channel structure, realizes a self-calibration function, eliminates the background interference and effectively improves the detection speed and accuracy.

Description

technical field [0001] The invention relates to non-invasive screening of major diseases, in particular to a method for standardized collection and sensing of clinical breath samples in non-invasive screening of lung cancer. Background technique [0002] Lung cancer is the cancer with the highest morbidity and mortality. Due to the fact that there are no obvious symptoms during the incubation period of lung cancer, and the commonly used diagnostic methods such as imaging, pathology, and microscopy are invasive and expensive, so most of the diagnosed patients are in the middle and late stages. And the survival time is short. However, if lung cancer can be detected in the early stage or even in the latent period, patients can reverse or prevent the occurrence of cancer by consciously improving their living habits, diet structure, and exercise habits to enhance anti-cancer immunity. When the human body breeds lung cancer, the tumor cells will produce certain special chemical c...

AI Technical Summary

Problems solved by technology

Therefore, the development of a non-invasive, rapid and low-cost lung cancer screening method can break through the key bottleneck of early diagnosis and low cure rate of lung cancer

The doctoral dissertation "Research on Rapid Noninvasive Screening Method for Lung Cancer with Nano-gold-Porphyrin Composite Sensor Array Chip" discloses a 6×6 sensor array chip to realize the detection of symbolic organic volatiles in lung cancer breath and clinical breath samples Rapid identification and detection, but most of the research is on the identification and detection of lung cancer markers, the number of clinical samples involved is relatively small, and the factors affecting clinical samples are not considered comprehensively when collecting

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