Gene positioning method and device, computer equipment and storage medium

A gene mapping and gene technology, applied in the fields of instrumentation, hybridization, sequence analysis, etc., can solve the problems of large number of genes and difficult to locate accurately, and achieve the effect of improving efficiency, narrowing detection range and improving data processing efficiency.

Pending Publication Date: 2020-03-24
PING AN TECH (SHENZHEN) CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The embodiment of the present invention provides a gene location method, device, computer equipment and storage medium to solve the problem that it is difficult to accurately locate the target abnormal gene due to the huge number of genes

Method used

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  • Gene positioning method and device, computer equipment and storage medium
  • Gene positioning method and device, computer equipment and storage medium
  • Gene positioning method and device, computer equipment and storage medium

Examples

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example 1

[0086] Example 1, since the standard gene motif and the potential abnormal motif are DNA sequence motifs, by extracting the feature vectors of the standard gene motif and the potential abnormal motif, in order to calculate the standard gene motif and potential abnormal motif using the vector similarity calculation formula The topological similarity value of the abnormal motif, the vector similarity calculation formula includes but not limited to the Euclidean distance calculation formula.

example 2

[0087] Example 2, perform topological similarity calculation on standard gene motifs and potential abnormal motifs, through the topological similarity calculation formula Calculate the topological similarity value of standard gene motifs and potential abnormal motifs, where, C D stands for the standard gene motif, C P represents a potential anomalous motif; d ij Represents the distance between nodes i and j; M is the number of point pairs between the two motifs. d in this example ij Including but not limited to using the shortest path calculation formula to obtain, which can be done through python.

[0088] S602: Sort the topological similarity values, and obtain a sorted list of similarity values.

[0089] Specifically, after the topological similarity value is obtained, the size of the topological similarity value is sorted to form a sorted list of similarity values, so that the target abnormal gene can be obtained intuitively and quickly. The higher the similarity bet...

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Abstract

The invention discloses a gene positioning method and device, computer equipment and a storage medium. The gene positioning method comprises the following steps: acquiring to-be-processed gene data, wherein the to-be-processed gene data comprises to-be-detected whole genome sequencing data and to-be-detected transcriptome data; carrying out low-frequency mononucleotide polymorphism screening on the whole to-be-detected genome sequencing data to obtain an initial gene list; performing gene co-expression network analysis on the initial gene list and the to-be-detected transcriptome data to obtain a linkage gene list; projecting the initial gene list and the linkage gene list into a gene regulation and control network to obtain a potential abnormal motif; obtaining a standard gene motif, andperforming topological similarity calculation on the standard gene motif and the potential abnormal motif to obtain a target abnormal gene. The gene positioning method provided by the invention can realize rapid and accurate positioning of abnormal genes.

Description

technical field [0001] The invention relates to the technical field of gene detection, in particular to a gene positioning method, device, computer equipment and storage medium. Background technique [0002] The current genetic material is affected by the environment or other factors to form abnormal genes. These abnormal genes may be disease-causing genes, such as diabetes-causing genes, etc.; they may also be genes with special functions, such as plant disease resistance genes. Precisely locating these abnormal genes can assist medical staff to identify diseases or assist researchers in research. However, the number of genes in a certain genetic material is huge, and it is difficult to accurately locate these abnormal genes. Contents of the invention [0003] Embodiments of the present invention provide a gene location method, device, computer equipment, and storage medium to solve the problem that it is difficult to accurately locate target abnormal genes due to the hug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B25/10G16B30/00
CPCG16B25/10G16B30/00
Inventor 廖希洋欧秋雨
Owner PING AN TECH (SHENZHEN) CO LTD
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