High frequency bipolar unrecoverable electroporation system

Abstract

The invention relates to a high frequency bipolar unrecoverable electroporation system. The high frequency bipolar unrecoverable electroporation system comprises an upper layer information managementmodule, a lower computer control module and a bipolar high voltage pulse discharging circuit, wherein the upper layer information management module is used for receiving set working parameters, and transmitting the received working parameters to the lower computer control module, and then a control signal is generated and transmitted to the bipolar high voltage pulse discharging circuit to producebipolar high voltage pulse. Compared with a conventional unipolar irreversible electroporation pulse sequence, the high frequency bipolar unrecoverable electroporation system can better and more uniformly increase the induced transmembrane potential of cells which are tightly arrayed to a simulation electroporation threshold, so that an ablation region is more uniform; and through the adoption ofthe high frequency bipolar unrecoverable electroporation system disclosed by the invention, favorable tumor ablation effects and the purpose of restraining the growth of tumor can be achieved, and the high frequency bipolar unrecoverable electroporation system has favorable safety and favorable validity.

Description

technical field [0001] The invention relates to the technical field of medical equipment for treating tumors, in particular to a high-frequency bipolar irreversible electroporation system. Background technique [0002] Tumor is a common and frequently-occurring disease, among which malignant tumor is the most serious disease that endangers human health. Since the pathogenesis and etiology of malignant tumors are not yet fully understood, fundamental preventive measures are lacking. So far, humans have not been able to cure malignant tumors like other common and frequently-occurring diseases. Due to the refractory nature of malignant tumors, scholars from various countries have treated malignant tumors through a combination of surgery, radiotherapy and chemotherapy for centuries in order to achieve a longer survival period. However, radiotherapy and chemotherapy have a great impact on human immunity and seriously affect the quality of life. [0003] Irreversible Electropor...

AI Technical Summary

Problems solved by technology

[0004] Although IRE has good clinical prospects, the existing irreversible electroporation uses unipolar high-voltage discharge pulses to act on cells. When this technology is used to irreversibly ablate human tumor cells, at the moment of pulse discharge It will cause the patient's muscles to twitch substantially, induce the patient's limbs to move substantially, and seriously affect the position fixation of the discharge electrode and the therapeutic effect

Therefore, the current implementation of such an operation requires tracheal intubation, general anesthesia, injection of muscle relaxants, and ventilator assistance, and cannot be performed under local anesthesia as conveniently as most interventional minimally invasive operations currently used in clinical practice , the operation process is cumbersome, the cost is high, and it increases the complexity and risk of the ablation operation, and may cause some complications, thus limiting the application and promotion of this technology

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