System and method for producing 90Y based on electron accelerator and 91Zr

Abstract

The invention discloses a system and method for producing 90Y based on an electron accelerator and 91Zr. The system comprises an electron generation section, an electron acceleration section, an electron-photon conversion part, a target irradiation part, a first cooling part, a second cooling part and a collection part. The invention provides a novel 90Y production mode based on the electron accelerator and the 91Zr, defects of an existing production mode are avoided, portability and safety of 90Y production are improved, and cost is reduced.

Description

technical field [0001] The invention belongs to the application field of nuclear technology, in particular to a 91 Zr 90 Y production system. Background technique [0002] 90 Y is an important medical radionuclide and has broad application prospects in radioimmunotherapy (RIT) of tumors. It has an appropriate physical half-life (T=64.0h), emits pure β ﹣ Particles; high β energy (maximum energy 2.3MeV, average energy 0.93MeV); average tissue range 2.5mm, maximum 11.9mm, calculated on the basis of a cell diameter of 20um, can kill cells within the range of 150-200 cell diameters, at 500 - 600 cell diameters have a killing effect and decay fonts 90 Zr is stable and non-toxic. [0003] 90 There are two production methods for Y: one is to use neutron irradiation in the reactor to irradiate high-purity 89 Y 2 o 3 target production 90 Y. Reactor Irradiation Production 90 Y is to use 89 Y(n,γ) 90 Y response, will 89 Y 2 o 3 The target is irradiated in the reactor t...

AI Technical Summary

Problems solved by technology

from 90 Separation in Sr decay equilibrium system 90 The operation of Y is relatively simple, no neutron source is required, and it can be produced in a place far away from the reactor, and the resulting 90 The specific activity of Y is higher, but this method will inevitably bring a small amount of highly toxic 90 Defilement of Sr, causing harm to the human body

[0004] Patent CN108028086A proposes an electron accelerator-based 90 The Y production method is to bombard high atomic number substances with electron beams to generate photoneutrons, which further interact with natural zirconium or concentrated zirconium materials. 90 Y, the reaction process utilized by this patent is 90 Zr(n,p) 90 Y reaction, but the patent mentions that the neutron energy requirement is higher, it needs to be between 4.7MeV and 12.1MeV, and it is almost difficult to cut off high-energy and low-energy neutrons at the same time. The requirements for the sub-moderation shaping device are also very high, which increases the cost and complexity of the system

On the other hand, when high-energy electrons bombard a high-atomic-number target, sufficient neutrons must be produced, and higher-level accompanying bremsstrahlung photons must be produced, neutrons must be slowed down to the use region (4.7MeV-12.1MeV ) while filtering the accompanying bremsstrahlung photons in the beam to a lower level, it is very difficult

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