Development of biomarker for ketogenic diet-based cancer treatment
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A ketogenic diet and cancer technology, applied in the field of biomarker development in the treatment of cancer ketogenic diet, can solve the problem of unknown details of the mechanism of action of ketogenic diet in cancer patients
Pending Publication Date: 2020-05-12
OSAKA UNIV +1
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However, the effectiveness of ketogenic diet therapy has not been confirmed for all cancer patients, and the details of the mechanism of action of the effect of ketogenic diet in cancer patients are still unknown
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[0018] Hereinafter, embodiments of the present invention will be described in detail.
[0019] In the present invention, the ketogenic diet refers to a diet in which the ketogenic ratio (lipid: (protein+carbohydrate)) is about 2:1 to 1:1 by weight. The ketogenic diet therapy refers to taking such a ketogenic diet for a predetermined period of time (for example, 3 months), and there are no special restrictions on other nutrients. In the ketogenic diet therapy, the required trace elements and vitamins can be properly ingested using nutritional supplements.
[0020] "Cancer" as used herein includes, for example, tumors in which normal cells undergo mutations. Malignant tumors may arise from all organs and tissues in the body. Examples of cancer patients in this specification include lung cancer, ovarian cancer, bladder cancer, lip adenoid cystic carcinoma, kidney cancer, urothelial carcinoma, colorectal cancer, prostate cancer, and glioblastoma multiforme , pancreatic cancer, ...
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Abstract
Provided are a method for selecting cancer patients for which ketogenic diet therapy would be effective, and a method for predicting the effectiveness of ketogenic diet therapy on cancer patients. Theselection method is characterized by obtaining, from blood serum derived from a cancer patient prior to ingesting a ketogenic diet, analysis results for at least one pre-ingestion candidate substanceselected from the group consisting of acylcarnitine(12:0), acylcarnitine(12:1)-2, acylcarnitine(12:1)-3, acylcarnitine(14:1)-1, acylcarnitine(14:2)-1, acylcarnitine(14:2)-2, acylcarnitine(14:3)-2, acylcarnitine(16:1), acylcarnitine(16:2), anandamide, heptadecenoic acid, hypotaurine, linoleoylethanolamide, palmitoleic acid, palmitoylcarnitine, phytosphingosine, quinic acid, uric acid, alanine, citrulline, tryptophan, and lysine, and using the analysis results as an indicator.
Description
technical field [0001] The present invention relates to the development of biomarkers in the treatment of cancer with a ketogenic diet. Specifically, it relates to a method for selecting cancer patients who are effective in ketogenic diet therapy, and a method for predicting the effectiveness of ketogenic diet therapy for cancer patients. Background technique [0002] A "ketogenic diet" is known as one type of dietary therapy. "Ketogenic diet" is a high-fat food that restricts carbohydrates, and 60-90% of energy intake is taken from fat. Therefore, a "ketogenic diet" is utilized as a diet for treating patients requiring a carbohydrate-restricted diet, such as children with epilepsy (for example, Patent Document 1). [0003] In recent years, dietary therapy using this "ketogenic diet" has been proposed as a treatment method for cancer patients (for example, Patent Document 2). Cases have been found showing dramatic clinical results with ketogenic diet therapy. However, th...
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