Hemostatic fabric containing trypsin and preparation method of hemostatic fabric

A technology of trypsin, fabric, applied in the field of biomedical materials

Active Publication Date: 2020-06-09
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] Aiming at the deficiencies of the prior art, the first technical problem to be solved by the present invention is to provide a hemostatic fabric with strong molecular sieve and fiber, high hemostatic performance and high safety in the hemostatic process without adding an adhesive. The molecular sieve in the hemostatic fabric still maintains the original large effective specific surface area and strong pore material exchange capacity, and trypsin can be efficiently combined with the molecular sieve

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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  • Hemostatic fabric containing trypsin and preparation method of hemostatic fabric
  • Hemostatic fabric containing trypsin and preparation method of hemostatic fabric
  • Hemostatic fabric containing trypsin and preparation method of hemostatic fabric

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0119] The manufacture method of Y-type molecular sieve cotton fiber hemostatic fabric of the present invention comprises the following steps:

[0120] ① Prepare the molecular sieve precursor solution, according to the following molar ratio 10Na 2 O: Al 2 o 3 :9SiO2 2 :200H 2 O constitutes the starting material to synthesize the molecular sieve precursor solution. The molecular sieve precursor solution is mixed with cotton fiber, and the mass ratio of cotton fiber to molecular sieve precursor solution is 1:20.

[0121] ②The cotton fiber and the homogeneously mixed molecular sieve precursor solution were transferred and heat-treated at 100°C for 24 hours to obtain a Y-type molecular sieve cotton fiber composite.

[0122] ③The Y-type molecular sieve cotton fiber compound is made into a suspension, and trypsin is contacted with it, and the trypsin is adsorbed on the Y-type molecular sieve cotton fiber compound to obtain a Y-type molecular sieve cotton fiber hemostatic fabric...

Embodiment 2

[0198] The preparation method of chabazite cotton fiber hemostatic fabric of the present invention comprises the following steps:

[0199] ① Prepare the molecular sieve precursor solution, according to the following molar ratio 10Na 2 O: Al 2 o 3 :9SiO2 2 :300H 2 O constitutes the starting material to synthesize the molecular sieve precursor solution. The molecular sieve precursor solution is mixed with cotton fiber, and the mass ratio of cotton fiber to molecular sieve precursor solution is 1:0.5.

[0200] ②The cotton fiber and the uniformly mixed molecular sieve precursor solution were heat-treated at 80°C for 36 hours to obtain the chabazite cotton fiber composite.

[0201] ③The chabazite cotton fiber compound is made into a suspension, and trypsin is contacted with it, and the trypsin is adsorbed on the chabazite cotton fiber compound to obtain a chabazite cotton fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 4:10 .

[0202] The obtaine...

Embodiment 3

[0204] The preparation method of the X-type molecular sieve silk fiber hemostatic fabric of the present invention comprises the following steps:

[0205] ① Prepare the molecular sieve precursor solution according to the following molar ratio 5.5Na 2 O:1.65K 2 O: Al 2 o 3 :2.2SiO2 2 :122H 2 O constitutes the starting material to synthesize the molecular sieve precursor solution. The molecular sieve precursor solution is mixed with the silk fiber, and the mass ratio of the silk fiber to the molecular sieve precursor solution is 1:10.

[0206] ②The silk fiber and the uniformly mixed molecular sieve precursor solution were heat-treated at 100°C for 12 hours to obtain the X-type molecular sieve silk fiber composite.

[0207] ③ The X-type molecular sieve silk fiber composite is made into a suspension, and trypsin is contacted with it, and the trypsin is adsorbed on the X-type molecular sieve silk fiber composite to obtain the X-type molecular sieve silk fiber hemostatic fabric...

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Abstract

The invention provides a hemostatic fabric containing trypsin. The hemostatic fabric contains a molecular sieve fiber compound and the trypsin, wherein the molecular sieve fiber compound contains molecular sieves and fibers, and the molecular sieves are distributed on the surfaces of the fibers and are in direct contact with the surfaces of the fibers; contact surfaces between the molecular sievesand the fibers do not contain binder and are inner surfaces, and the inner surfaces are rough planes, and growth matching coupling is formed between the molecular sieves and the fibers on the inner surfaces. By specifically combining the trypsin with the molecular sieve fiber compound and maintaining relatively high procoagulant activity, the hemostatic fabric with an excellent blood coagulationeffect is obtained. The preparation method of the hemostatic fabric is simple and low in cost, and the hemostatic fabric is convenient to use and can be widely applied to surgical hemostasis.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a trypsin-containing hemostatic fabric and a preparation method thereof. Background technique [0002] Humans (including animals) can be injured in a variety of situations. In some cases, the trauma and bleeding are minor and normal hemostasis requires only routine coagulation in addition to the application of simple first aid. Unfortunately, however, profuse bleeding can occur in many accidental situations, for example, from skin cuts or penetrating injuries (caused by knife cuts or bullets) resulting in aortic injury, most of a normal person's blood will be lost in a few minutes Drain and die. Therefore, in the first aid treatment of sudden accidents in daily life, the trauma hemostasis in the operation process of the hospital to the patient, especially in the rescue of the wounded soldiers in the war, it is very important to effectively stop the blee...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/44A61L15/38A61L15/40A61L15/18
CPCA61L15/44A61L15/38A61L15/40A61L15/18A61L2300/254A61L2300/418A61L2400/04A61L15/42A61L2400/12A61L15/22A61L15/425A61L15/24A61L15/26A61L15/32A61L17/005A61F13/00063A61F13/00008A61F13/00991A61L2300/102A61F2013/00472
Inventor 范杰余丽莎肖丽萍陈昊尚小强
Owner ZHEJIANG UNIV
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