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Hemostatic compound and preparation method thereof

A technology of complexes and detection methods, applied in the field of biomedical materials

Active Publication Date: 2019-06-07
杭州沸创生命科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] In view of the deficiencies of the prior art, the first technical problem to be solved by the present invention is to provide a hemostatic compound with strong molecular sieve and fiber, high hemostatic performance and high safety in the hemostatic process without adding an adhesive. The molecular sieve in the hemostatic compound still maintains the original large effective specific surface area and strong pore material exchange capacity

Method used

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  • Hemostatic compound and preparation method thereof
  • Hemostatic compound and preparation method thereof
  • Hemostatic compound and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0118] The preparation method of Y-type molecular sieve / cotton fiber hemostatic compound of the present invention comprises the following steps:

[0119] ① Prepare the molecular sieve precursor solution, according to the following molar ratio 10Na 2 O: Al 2 o 3 :9SiO2 2 :200H 2 O constitutes the starting material to synthesize the molecular sieve precursor solution. The molecular sieve precursor solution is mixed with cotton fiber, and the mass ratio of cotton fiber to molecular sieve precursor solution is 1:20.

[0120] ②The cotton fiber and the homogeneously mixed molecular sieve precursor solution were transferred and heat-treated at 100°C for 24 hours to obtain a Y-type molecular sieve / cotton fiber hemostatic compound.

[0121] Randomly take 10 samples of the prepared Y-type molecular sieve / cotton fiber hemostatic compound in different parts, and analyze the content of Y-type molecular sieve on the fiber surface with a thermogravimetric analyzer. The content of 10 sam...

Embodiment 2

[0189] The preparation method of chabazite / cotton fiber hemostatic compound of the present invention comprises the following steps:

[0190] ① Prepare the molecular sieve precursor solution, according to the following molar ratio 10Na 2 O: Al 2 o 3 :9SiO2 2 :300H 2 O constitutes the starting material to synthesize the molecular sieve precursor solution. The molecular sieve precursor solution is mixed with cotton fiber, and the mass ratio of cotton fiber to molecular sieve precursor solution is 1:0.5.

[0191] ②Heat-treat the cotton fiber and the homogeneously mixed molecular sieve precursor solution at 80°C for 36 hours to obtain the chabazite / cotton fiber hemostatic composite.

[0192] Randomly take 10 samples of the prepared chabazite / cotton fiber hemostatic compound in different parts, and analyze the content of chabazite on the fiber surface, and the average content of molecular sieve on the fiber in the 10 samples can be obtained as 25wt%, and the sample standard Th...

Embodiment 3

[0194] The preparation method of the X-type molecular sieve / silk fiber hemostatic compound of the present invention comprises the following steps:

[0195] ① Prepare the molecular sieve precursor solution according to the following molar ratio 5.5Na 2 O:1.65K 2 O: Al 2 o 3 :2.2SiO2 2 :122H 2 O constitutes the starting material to synthesize the molecular sieve precursor solution. The molecular sieve precursor solution is mixed with silk fiber, and the mass ratio of silk fiber and molecular sieve precursor solution is 1:10.

[0196] ②The silk fiber and the homogeneously mixed molecular sieve precursor solution were heat-treated at 100°C for 12 hours to obtain the X-type molecular sieve / silk fiber hemostatic composite.

[0197] Randomly take 8 samples of the prepared X-type molecular sieve / silk fiber hemostatic composite in different parts, analyze the content of X-type molecular sieve on the fiber surface, and the average content of molecular sieve on the fiber in the eig...

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Abstract

The invention provides a hemostatic compound. The hemostatic compound comprises molecule sieves and fibers, the molecule sieves are distributed on the surfaces of the fibers and make direct contact with the surfaces of the fibers, the particle size D90 of the molecule sieves is 0.01-50 [mu]m, the particle size D50 of the molecule sieves is 0.005-30 [mu]m, the content of a binder on the contact surface of the molecule sieves and the fibers is 0, the contact surface of the molecule sieves and the fibers is an inner surface which is a rough plane, growth matched coupling is formed between the molecule sieves and the fibers on the inner surface, a non-contact surface of the molecule sieves and the fibers is an outer surface which is a non-plane, and the inner surface and the outer surface areboth composed of molecule sieve nanoparticles. The invention also provides a preparation method and an application of the hemostatic compound. The hemostatic compound requires no binder, increases theblood clotting response speed and plays a rapid blood clotting role, so that the problem that the hemostatic compound loses the hemostatic effect easily due to the fact that molecule sieves fall fromthe surface of the fibers easily is solved, the problem that easily falling molecule sieves can stick to wound parts to cause thrombus is solved, and the performance and safety of the hemostatic compound are improved.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a hemostatic compound and a preparation method thereof. Background technique [0002] Humans (including animals) can be injured in a variety of situations. In some cases, the trauma and bleeding are minor, and normal hemostasis requires only routine coagulation, in addition to the application of simple first aid. Unfortunately, however, profuse bleeding can occur on other occasions. These situations often require specialized equipment and materials, as well as professionally trained personnel to administer proper rescue. If such assistance is not readily available, death from excessive blood loss may occur. Hemorrhagic death is a very serious global problem with an estimated 1.9 million hemorrhagic deaths worldwide each year, 1.5 million of which are due to physical trauma. Of these, these 1.5 million deaths accounted for nearly 75 million years of li...

Claims

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Application Information

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IPC IPC(8): A61L24/02A61L24/04
CPCA61L15/18A61L2400/04A61L2400/12A61F2013/00463A61K9/7007A61K45/06A61P7/04A61L2300/418A61F13/00063A61F13/14A61L15/425A61F13/01008
Inventor 范杰余丽莎肖丽萍陈昊尚小强
Owner 杭州沸创生命科技股份有限公司
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