A kind of hemostatic compound and preparation method thereof

Abstract

The present invention provides a hemostatic complex, the hemostatic complex comprises a molecular sieve and a fiber, the molecular sieve is distributed on the surface of the fiber and is in direct contact with the surface of the fiber, the particle size D90 of the molecular sieve is 0.01-50 μm, and the molecular sieve is The particle size D50 is 0.005-30 μm, the binder content of the contact surface between the molecular sieve and the fiber is 0, the contact surface between the molecular sieve and the fiber is the inner surface, and the inner surface is a rough plane. A growth matching coupling is formed between the molecular sieve and the fiber on the surface, the non-contact surface of the molecular sieve and the fiber is the outer surface, the outer surface is non-planar, and the inner surface and the outer surface are both composed of molecular sieve nanoparticles. The present invention also provides the preparation method and use of the hemostatic complex. The hemostatic compound of the present invention does not need to add a binder, and accelerates the speed of the coagulation reaction, plays the role of rapid coagulation, solves the problem that the hemostatic compound easily loses the hemostatic effect caused by the molecular sieve easily falling off the surface of the fiber, and solves the problem of easy Some of the detached molecular sieves will adhere to the wound and cause the problem of thrombosis, which improves the performance and safety of the hemostatic complex.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a hemostatic compound and a preparation method thereof. Background technique [0002] Humans (including animals) can be injured in a variety of situations. In some cases, the trauma and bleeding are minor and normal hemostasis requires only routine coagulation in addition to the application of simple first aid. Unfortunately, however, profuse bleeding can occur on other occasions. These situations often require specialized equipment and materials, as well as professionally trained personnel to administer proper rescue. If such assistance is not readily available, death from excessive blood loss may occur. Hemorrhagic death is a very serious global problem with an estimated 1.9 million hemorrhagic deaths worldwide each year, 1.5 million of which are due to physical trauma. Of these, these 1.5 million deaths accounted for nearly 75 million years of life...

AI Technical Summary

Problems solved by technology

[0019] In view of the deficiencies in the prior art, the first technical problem to be solved by the present invention is to provide a hemostatic compound with strong molecular sieve and fiber, high hemostatic performance and high safety in the hemostatic process without adding an adhesive. The molecular sieve in the hemostatic compound still maintains the original large effective specific surface area and strong pore material exchange capacity

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