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A kind of hemostatic fabric containing trypsin and its preparation method

A trypsin and fabric technology, applied in the field of biomedical materials

Active Publication Date: 2020-12-22
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] Aiming at the deficiencies of the prior art, the first technical problem to be solved by the present invention is to provide a hemostatic fabric with strong molecular sieve and fiber, high hemostatic performance and high safety in the hemostatic process without adding an adhesive. The molecular sieve in the hemostatic fabric still maintains the original large effective specific surface area and strong pore material exchange capacity, and trypsin can be efficiently combined with the molecular sieve

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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  • A kind of hemostatic fabric containing trypsin and its preparation method
  • A kind of hemostatic fabric containing trypsin and its preparation method
  • A kind of hemostatic fabric containing trypsin and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0119] The manufacture method of Y-type molecular sieve cotton fiber hemostatic fabric of the present invention comprises the following steps:

[0120] ① Prepare the molecular sieve precursor solution, according to the following molar ratio 10Na 2 O: Al 2 o 3 :9SiO2 2 :200H 2 O constitutes the starting material to synthesize the molecular sieve precursor solution. The molecular sieve precursor solution is mixed with cotton fiber, and the mass ratio of cotton fiber to molecular sieve precursor solution is 1:20.

[0121] ②The cotton fiber and the homogeneously mixed molecular sieve precursor solution were transferred and heat-treated at 100°C for 24 hours to obtain a Y-type molecular sieve cotton fiber composite.

[0122] ③The Y-type molecular sieve cotton fiber compound is made into a suspension, and trypsin is contacted with it, and the trypsin is adsorbed on the Y-type molecular sieve cotton fiber compound to obtain a Y-type molecular sieve cotton fiber hemostatic fabric...

Embodiment 2

[0198] The preparation method of chabazite cotton fiber hemostatic fabric of the present invention comprises the following steps:

[0199] ① Prepare the molecular sieve precursor solution, according to the following molar ratio 10Na 2 O: Al 2 o 3 :9SiO2 2 :300H 2 O constitutes the starting material to synthesize the molecular sieve precursor solution. The molecular sieve precursor solution is mixed with cotton fiber, and the mass ratio of cotton fiber to molecular sieve precursor solution is 1:0.5.

[0200] ②The cotton fiber and the uniformly mixed molecular sieve precursor solution were heat-treated at 80°C for 36 hours to obtain the chabazite cotton fiber composite.

[0201] ③The chabazite cotton fiber compound is made into a suspension, and trypsin is contacted with it, and the trypsin is adsorbed on the chabazite cotton fiber compound to obtain a chabazite cotton fiber hemostatic fabric, and the mass ratio of trypsin to molecular sieve is 4:10 .

[0202] The obtaine...

Embodiment 3

[0204] The preparation method of the X-type molecular sieve silk fiber hemostatic fabric of the present invention comprises the following steps:

[0205] ① Prepare the molecular sieve precursor solution according to the following molar ratio 5.5Na 2 O:1.65K 2 O: Al 2 o 3 :2.2SiO2 2 :122H 2 O constitutes the starting material to synthesize the molecular sieve precursor solution. The molecular sieve precursor solution is mixed with the silk fiber, and the mass ratio of the silk fiber to the molecular sieve precursor solution is 1:10.

[0206] ②The silk fiber and the uniformly mixed molecular sieve precursor solution were heat-treated at 100°C for 12 hours to obtain the X-type molecular sieve silk fiber composite.

[0207] ③ The X-type molecular sieve silk fiber composite is made into a suspension, and trypsin is contacted with it, and the trypsin is adsorbed on the X-type molecular sieve silk fiber composite to obtain the X-type molecular sieve silk fiber hemostatic fabric...

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Abstract

The invention provides a trypsin-containing hemostatic fabric, the hemostatic fabric comprises molecular sieve fiber composite and trypsin, the molecular sieve fiber composite includes molecular sieve and fiber, and the molecular sieve is distributed on the surface of the fiber and directly connected with the Fiber surface contact; the binder content of the contact surface between the molecular sieve and the fiber is 0, the contact surface between the molecular sieve and the fiber is the inner surface, and the inner surface is a rough plane, and the molecular sieve and the fiber are on the inner surface A growth matching coupling is formed between them. The invention specifically combines trypsin with the molecular sieve fiber complex, and maintains high procoagulant activity, thereby obtaining a hemostatic fabric with excellent coagulation effect. The hemostatic fabric of the invention has simple preparation method, low cost and convenient use, and can be widely used in wound and operation hemostasis.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a trypsin-containing hemostatic fabric and a preparation method thereof. Background technique [0002] Humans (including animals) can be injured in a variety of situations. In some cases, the trauma and bleeding are minor and normal hemostasis requires only routine coagulation in addition to the application of simple first aid. Unfortunately, however, profuse bleeding can occur in many accidental situations, for example, from skin cuts or penetrating injuries (caused by knife cuts or bullets) resulting in aortic injury, most of a normal person's blood will be lost in a few minutes Drain and die. Therefore, in the first aid treatment of sudden accidents in daily life, the trauma hemostasis in the operation process of the hospital to the patient, especially in the rescue of the wounded soldiers in the war, it is very important to effectively stop the blee...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/44A61L15/38A61L15/40A61L15/18
CPCA61L15/44A61L15/38A61L15/40A61L15/18A61L2300/254A61L2300/418A61L2400/04A61L15/42A61L2400/12A61L15/22A61F13/00063A61L17/005A61L15/32A61F13/00991A61L15/24A61L2300/102A61F2013/00472A61L15/26A61L15/425A61F13/01008
Inventor 范杰余丽莎肖丽萍陈昊尚小强
Owner ZHEJIANG UNIV
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