Self-assembly short-chain peptide and application of short-chain peptide in treatment of acne

A technology of self-assembling short peptides and acne, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, peptides, etc., which can solve the problems of long treatment period, achieve low toxicity and side effects, inhibit excessive proliferation, Applicable to a wide range of people

Active Publication Date: 2020-06-09
JINAN UNIVERSITY
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

In addition, acne can also be treated by methods such as Chinese medicine decoction and acupuncture, but the course of treatment is longer.

Method used

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  • Self-assembly short-chain peptide and application of short-chain peptide in treatment of acne
  • Self-assembly short-chain peptide and application of short-chain peptide in treatment of acne
  • Self-assembly short-chain peptide and application of short-chain peptide in treatment of acne

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Embodiment 1

[0034] 1. Cloning formation assay was used to determine the growth inhibitory effect of self-assembled short peptides on human sebocytes SZ95 (purchased from Suzhou Beina Chuanglian Biotechnology Co., Ltd.)

[0035] The cells in each group in the logarithmic growth phase were digested with trypsin and blown into single cells, diluted to a certain multiple and seeded in 6-well plates (1.2×10 6 cells / well) and swirl gently to disperse the cells evenly. Add 0 μM, 20 μM, 100 μM and 200 μM self-assembled short peptides to the wells and culture for 2 to 3 weeks, discard the medium, fix the cells, stain with crystal violet, take pictures and count the number of cell clones.

[0036] The result is as figure 1 As shown, the experimental results show that the self-assembled short peptide can inhibit the growth of human sebocytes (SZ95).

[0037] 2. CCK-8 method to detect the growth inhibitory effect of self-assembled short peptides on human sebocytes (SZ95)

[0038] Take human sebocy...

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Abstract

The invention discloses a self-assembly short-chain peptide and an application of the short-chain peptide in treatment of acne. The self-assembled short-chain peptide in the invention is a self-assembled short-chain peptide composed of 10 amino acid residues, and the amino acid sequence is shown as FFLQLQAEER. The self-assembled short-chain peptide can inhibit excessive proliferation of sebaceousglands and reduce secretion of skin oil, has smaller toxicity and side effects, is suitable for a wider population, has better transdermal properties, and can be used for acne resistance, especially for treatment of acne generated by changes in hormone levels during adolescence and pregnancy; and because the self-assembled short-chain peptide has only 10 amino acids, the short-chain peptide is self-assemble into nanospheres through modification, so that the self-assembled short-chain peptide has better stability, can continuously act on a treatment site, and has a significant effect.

Description

technical field [0001] The invention belongs to the field of biomedicine, in particular to a self-assembled short peptide and its application in treating acne. Background technique [0002] Acne is the most common chronic inflammatory disease of the pilosebaceous unit during adolescence. Due to the complex causes of its pathogenesis, the pathogenesis has not yet been fully understood. Currently, hypersebum secretion in patients' skin, abnormal intrafollicular keratinization, colonization of P. acnes in pilosebaceous ducts, and inflammatory mediators are considered as key factors in the development of acne lesions. Due to air pollution, stress caused by the accelerated pace of modern life, and imbalanced sex hormone levels, the number of people suffering from acne is on the rise. In addition, certain drugs can also cause acne by stimulating the sebaceous glands, especially corticosteroids and anabolic steroids. For example, the formation of facial "rosacea" is caused by the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/06A61K38/08A61K9/06A61K47/36A61P17/10A61K8/64A61Q19/00
CPCA61K8/64A61K9/06A61K38/00A61K47/36A61Q19/00A61P17/10C07K7/06
Inventor 陈小佳王磊
Owner JINAN UNIVERSITY
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