11results about How to "Inhibit hyperproliferation" patented technology

The invention discloses application of an AXL inhibitor in preparation of a medicine for treating heart failure, and relates to the field of pharmacy. The invention provides application of an AXL inhibitor in a medicine for treating heart failure. The AXL inhibitor can remarkably inhibit abnormal activation of fibroblasts and can remarkably improve the heart function of a mouse with heart failure.

The invention discloses a gene engineering exosome and a slow release method and application thereof, the gene engineering exosome is derived from human adipose-derived stem cells, si-tgfbr2 is loaded in the gene engineering exosome, the si-tgfbr2 is specific siRNA aiming at a Tgfbr2 gene, and the gene engineering exosome can regulate and control proliferation of VSMCs, inhibit transformation of the VSMCs from a contraction phenotype to a synthetic phenotype when the VSMCs are stimulated, and inhibit the growth of the VSMCs. According to the present invention, the gene engineering exosome can be used to maintain the normal structure and the function of the blood vessel, and the sustained release effect of the content in the gene engineering exosome can be achieved by wrapping the gene engineering exosome in the PHA biodegradable material, such that the local treatment concentration can be easily stabilized, the drug administration frequency can be easily reduced, the lasting time of the treatment effect can be easily prolonged, and the treatment gene can be effectively delivered to the target cell; the treatment effect is improved; when being used for modifying a small-caliber artificial blood vessel, the small-caliber artificial blood vessel can be improved in biocompatibility and functionality, and can be prevented from being implanted into the blood vessel for remodeling unbenign hyperplasia stenosis; the invention not only provides a new thought and method for the treatment of vascular diseases, but also has important clinical application value and popularization prospect.

The invention relates to application of chenodeoxycholic acid or pharmaceutically acceptable salt thereof in preparation of a medicine for treating acne. The chenodeoxycholic acid disclosed by the invention can be a natural organic compound or a synthetic organic compound, has relatively strong propionibacterium acnes inhibitory activity and a pharmacodynamic effect of resisting lipid secretion, and is used as an active component to be prepared into a pharmaceutical composition for treating acnes together with a pharmaceutically acceptable carrier.

The invention belongs to the technical field of plant tissue culture, and particularly relates to a rapid tissue propagation method for radix ranunculi ternati. The rapid propagation method for the radix ranunculi ternati tissue comprises the following steps: (1) seed selection and disinfection: selecting vigorous seeds, cleaning the seeds, soaking the seeds with mercury bichloride, disinfecting the seeds with alcohol, and finally washing the seeds with sterile water; (2) preparing a primary induction culture medium: preparing the primary induction culture medium; (3) seed induction and proliferation: inoculating the disinfected seeds on a primary induction culture medium, and culturing; after 4-6 weeks of culture, the seeds germinate into plantlets; transferring the plantlets to a subculture induction medium for multiplication culture, and subculturing once every 3-4 weeks; (4) rooting culture: transferring the proliferation seedlings to a rooting culture medium, and culturing for 2-3 weeks until the adventitious buds can root to form complete plants; and (5) seedling hardening and transplanting. The method can improve the rooting rate and shorten the propagation time at the same time.

The present application relates to an optimization method suitable for Agrobacterium transient infection conditions of Phalaenopsis, the explant of Phalaenopsis after Agrobacterium infection treatment is placed in the first co-culture condition for culture; the cut around, tissue edge and surface state of the explant are observed; when the cut around appears browning, and at least one of the accompanying tissue edge water spot or surface loss of luster, the host defense threshold is determined; after reaching the host defense threshold, the residual Agrobacterium liquid on the surface of the explant is removed, and the explant is transferred to the second co-culture condition for continuous culture. Realize the precise regulation of co-culture, improve the accuracy of threshold identification, and optimize the matching degree of Agrobacterium infection. Adopt hierarchical film removal, asymmetric co-culture and partition suction and other operations, inhibit the excessive proliferation of Agrobacterium, accurately remove the residual bacterial liquid, while ensuring the activity of the explant, significantly improve the infection efficiency, expression stability and method repeatability.

The present application relates to the field of cosmetic technology, and specifically discloses a microecological regulation composition, a preparation method and an application. A microecological regulation composition, comprising the following weight percentage components: lactobacillus fermentation lysate 0.1-5%; lactobacillus / soy milk fermentation product filtrate 0.05-2%; α-glucan oligosaccharide 0.1-10%; compound plant extract 0.2-20%; moisturizer 1-35%; solvent 0.1-10%; the remainder is deionized water; its preparation method is: lactobacillus fermentation lysate, lactobacillus / soy milk fermentation product filtrate, α-glucan oligosaccharide, compound plant extract, moisturizer, solvent and water are stirred and mixed to obtain. The microecological regulation composition of the present application can effectively maintain the balance of skin microecology and has a prominent improvement effect on acne.

The invention relates to application of a PDGFRA inhibitor in preparation of a medicine for treating astroblastoma. Experiments prove that the PDGFRA inhibitor can remarkably inhibit excessive proliferation of astroblastoma cells, but does not influence proliferation of normal cells of the same type, so that the PDGFRA inhibitor can relieve, improve or treat the astroblastoma or delay the process of the astroblastoma, and therefore, the PDGFRA inhibitor is expected to become a candidate therapeutic drug for the astroblastoma and has a good application prospect. The clinical application prospect is relatively great.

The application provides a fusion protein for inhibiting a Wnt signal path and application thereof, and relates to the field of biological medicines, and comprises the following: a first peptide segment, wherein the first peptide segment comprises a FU1 fragment; a second peptide segment, wherein the second peptide segment comprises a DRPB fragment; and the first peptide segment is connected with the second peptide segment. The prepared fusion protein can effectively inhibit the Wnt signal path, can inhibit excessive proliferation of cells under a pathological condition of abnormal activation of Wnt, and can effectively regulate the Wnt signal path.

The application discloses a 3-hydroxypyrrolidine derivative and a preparation method and application thereof. The structural formula of the 3-hydroxypyrrolidine derivative is shown in formula (I) or formula (II). The 3-hydroxypyrrolidine derivatives shown in formula (I) and formula (II) are non-diastereoisomers. The 3-hydroxypyrrolidine derivative provided by the application can inhibit the proliferation of RAW264.7 cells, and further inhibit the excessive proliferation of macrophages in immune cells to a certain extent. The 3-hydroxypyrrolidine diastereoisomers are obtained through one-pot reaction of a suitable reaction substrate under the action of a copper catalyst, the reaction condition is simple, and a good yield is obtained, so that the problems of needing to pass through multiple synthesis steps, high reaction risk, low reaction efficiency and low yield in the prior art are solved, and a new green synthesis route for the preparation of the 3-hydroxypyrrolidine derivative is provided.

The utility model discloses a sample constant-temperature preservation device for collecting pathogenic microorganisms, and particularly relates to the technical field of medical instruments, the sample constant-temperature preservation device comprises a moving assembly, the rear part of the moving assembly is fixedly connected with a fixed assembly, the front part of the moving assembly is rotatably connected with a placing assembly, and the moving assembly is fixedly connected with the fixed assembly. A containing plate is slidably connected to an inner cavity of the moving assembly, a constant-temperature assembly is fixedly connected to the inner cavity of the moving assembly, and a scraping assembly is rotationally connected to the front portion of the constant-temperature assembly. According to the sample constant-temperature storage device for collecting pathogenic microorganisms, the interior of the first shell can be cooled through the designed power assembly and the constant-temperature assembly, so that the interior of the first shell is always kept at a low temperature, and when the sample is placed for a long time, the sample cannot be deteriorated, so that the sample is prevented from losing the effect; the specimen for microbiological examination can be preserved at low temperature for 24 hours at most, and the temperature range is beneficial to keeping the activity of microorganisms.

This invention discloses a collagen-based anti-corrosion coating with tissue repair properties, its preparation method, and its applications, belonging to the field of medical coating technology. This invention designs a novel self-healing anti-corrosion coating and loads collagen onto the coating using excipients, achieving a deep integration of anti-corrosion protection and biological function. The prepared collagen-based anti-corrosion coating is firmly bonded to a magnesium alloy substrate via covalent bonds. After 4 weeks of in vivo implantation, no cracking or detachment was observed, the stent structure maintained good integrity, and it provides continuous radial support, offering sufficient time for vascular repair. This provides a feasible solution for the clinical translation of next-generation biodegradable magnesium-based vascular stents.