87results about How to "Inhibit hyperproliferation" patented technology

The invention discloses a dressing composition used for inhibiting scars and accelerating wound healing and application thereof. The dressing composition consists of chitosan, acidic polysaccharide and panax notoginseng saponins in a weight proportion of 100:10-50:10-100, wherein the chitosan is selected from chitosan, chitosan lactate, acetate and hydrochloride; the acidic polysaccharide is selected from sodium carboxymethyl chitosan, sodium hyaluronate, zinc hyaluronate, sodium alginate and sodium carboxymethyl cellulose; and the panax notoginseng saponins accounts for no less than 40.0 percent of the total weight of ginsenosides Rg1 and Rb1. The formulations of the dressing composition are xerogel powder, capsules, gel membranes, hydrogels and fiber coatings. The dressing composition is used for wounds, burns, scalds, crush injuries, skin ulcers, gastroenteric ulcers and no healing of the wounds, has the advantages of rapid hemostasis, exudate reduction, moisturizing, air permeability, bacteriostasis, inflammation diminishing, itch relieving, no adhesion, effective inhibition of scarring, remarkable reduction of wound healing time and no need of replacing dressings, so that thedressing composition basically meets requirements of perfect functional external dressings.

The invention provides a blood vessel drug elution bracket with coating layers and the preparation method. The blood vessel drug elution bracket with coating layers comprises: a: a bare stents with supporting role; b: a non-degradation bioactive coating coated on the surface of the bare stents; and c: a degradation bioactive drug coating coated on the surface of the bioactive coating. The blood vessel drug elution bracket with coating layers has the advantages of not only obvious anti-restenosis properties, but also ability to decrease the occurrence of thrombus for the stable bioactive coating; simultaneously, the bioactive coating can intensify the adsorption force of the drug coating on the bracket surface, reduce the crack, upwrap and shedding during the using process of the drug coating, thus improving the effectiveness and safety of the drug bracket.

The invention discloses a medical degradable Zn-Cu-X alloy material and a preparation method thereof. The alloy material includes the following components in percentage by weight: 1-10% of Cu, 0-4% of X and the balance Zn, wherein the element X is one of Mg, Ca, Sr, Si, Fe, Mn, Ag, Y, Nd, Gd, Er, Ho and Dy or is a mixture of more of Mg, Ca, Sr, Si, Fe, Mn, Ag, Y, Nd, Gd, Er, Ho and Dy. The invention further relates to the preparation method of the alloy material. The alloy material provided by the invention is a multi-element degradable Zn-based alloy material composed of the human nutrient elements Zn, Cu and X, which completely have biosecurity, has favorable biocompatibility, excellent mechanical properties and an adjustable and controllable corrosion rate, and has a favorable application prospect in the field of medical degradable inner implantation material.

The subject invention provides dipeptides useful in preventing pathological proliferation of blood vessels. The dipeptides of the subject invention are particularly advantageous because they are stable, bioavailable, and can be formulated in an aqueous solution.

A method for implanting the endothelial cells on the inner surface of artificial blood vessel features that a biomechanical method is used, that is, an external pulsive fluid shearing force increased step by step acts on the planted endothelial cells to make them be attached well on the inner surface of artificial blood vessel in advance.

The invention discloses an inductive uterine slow release system. The incidence of uterine adhesion after an induced abortion operation is high, the re-adhesion is serious after a uterine adhesion operation, and no good solution is available at present. The system comprises a uterus-shaped elastic balloon stent, a slow release drug film, a catheter and a one-way inflation valve, wherein the uterus-shaped elastic balloon stent is a hollow isosceles triangle structural body; waists of the isosceles triangle are 3.5cm; the bottom edge of the isosceles triangle is 3cm; one end of the catheter is connected and communicated with the vertex angle end of the uterus-shaped elastic balloon stent; the other end of the catheter is connected with the one-way inflation valve; a plurality of annular scales are arranged on the outer side face of one end, close to the uterus-shaped elastic balloon stent, of the catheter; and the one-way inflation valve comprises an inflation valve and a pressure sensor. The uterus-shaped elastic balloon stent is coated with the slow release drug film, and the slow release drug film is made of fibrin glue and contains a slow release drug. The system is simple in structure and easy to operate, does not injure a uterine cavity easily, and can effectively avoid the uterine adhesion.

The subject invention provides for the administration of docosahexaenoic acid in preventing pathological proliferation of blood vessels. The compositions of the subject invention are particularly advantageous because they are stable, bioavailable, and can be formulated in an aqueous solution.

This invention provides a novel method of treating psoriasis in humans by topical administration of a mixture consisting of copper lactate [Cu (C₃, H₅ O₃)₂. 2H₂O], zinc hydroxide Zn(OH)₂, trace amounts of cupric oxide and purified water by blunting the action of T cells present in the bleeding points located in and around the psoriatic lesions. When the bleeding points are absent in psoriatic lesions, this composition eliminates primary psoriatic symptoms such as inflammation, itching, rete ridges and tough red skin patches without curing psoriasis. The size and population of psoriatic lesions is also reduced. This composition is also very effective for providing instant relief from skin rash and itching.

The invention discloses bifidobacterium animalis capable of relieving psoriasis and application of the bifidobacterium animalis, and belongs to the technical field of microorganisms and medicines. Theinvention provides a bifidobacterium animalis CCFM1148, and the bifidobacterium animalis CCFM1148 can alleviate psoriasis, which is specifically reflected in that the bifidobacterium animalis CCFM1148 inhibits the excessive proliferation of psoriasis-like cortical forming cells, inhibits activation of an NF-kB signal path in psoriasis-like cortical forming cells, reduces the level of proinflammatory factor IL-6 in psoriasis-like cortical forming cells, and reduces the level of a proinflammatory factor IL-8 in psoriasis-like cortical cells, so that the bifidobacterium animalis CCFM1148 has a huge application prospect in preparation of products (such as daily chemical products or medicines) for preventing and/or treating psoriasis.

The invention relates to a retina pigment epithelial cell culture medium and an application thereof. The retina pigment epithelial cell culture medium comprises a first RPE (Retinal Pigment Epithelium) cell culture medium and a second RPE cell culture medium, wherein the first RPE cell culture medium and the second RPE cell culture medium are respectively used in 1.5 weeks, a RPE monolayer cell needed for cell replacement therapy can be quickly cultured; and the cultured RPE is polygonal, embedded and polarly-arranged monolayer cell and has the normal biological functions. Compared with the prior art, the RPE monolayer cell needed for cell replacement therapy can be quickly cultured in 1.5 weeks under the precondition that the conventional laboratory consumables are used; and the retina pigment epithelial cell culture medium is relatively low in cost and high in proliferation speed.

Disclosed is an application of M2 pyruvate kinase as drug target in the preparation of drugs for prevention and treatment of psoriasis.

The invention provides novel STAMP2 nucleic acid molecules, polypeptides, antibodies, and modulatory compounds for use in methods of diagnosing, treating, and preventing diseases and conditions of the prostate and testis, such as cancer.

The invention discloses traditional Chinese chinese preparation for treating gastro-esophageal reflex disease. Raw materials include, by weight part, from 10 to 15 parts of inula flower, from 5 to 10 parts of ruddle, from 10 to 15 parts of dry radix ginseng, from 5 to 10 parts of rhizoma pinelliae preparata, from 5 to 10 parts of radix glycyrrhizae preparate, from 12 to 18 parts of Sichuan coptischinensis, from 3 to 6 parts of fructus evodiae, from 15 to 20 parts of western tangkuei, from 10 to 15 parts of loquat leaves and from 1 to 3 parts of bitter platycodon grandiflorum. Efficiency of the traditional Chinese medicine preparation reaches 92.7%, and a good curative effect is obtained.

The invention discloses a process for preparing low-molecular-weight fucoidan, wherein the low-molecular-weight fucoidan is prepared through the process steps of hydrochloric acid degradation, desalination, ion exchange column elution and the like. Proved by pharmacological activity experiments, the low-molecular-weight fucoidan prepared by adopting the method disclosed by the invention is capable of obviously improving renal function, reducing proteinuria, slowing glomerular sclerosis and playing a role of protecting kidney. Proved by animal experiments, the effect of the low-molecular-weight fucoidan is obviously better than that of fucoidan with the same dose, so that the low-molecular-weight fucoidan disclosed by the invention can be used for preparing drugs for treating diabetic nephropathy or can be directly used as a drug for treating the diabetic nephropathy.

The invention relates to a preparation method and application of an amino-rich stent material modified by copper 4-carboxyphenyl porphyrin, a blood vessel stent material and application, and belongs to the technical field of biological material surface modification. The preparation method of the amino-rich stent material modified by copper 4-carboxyphenyl porphyrin includes the steps that copper 4-carboxyphenyl porphyrin is dissolved in an organic solvent, the pH value of a solution is adjusted to be 7+/-0.5, so that a copper 4-carboxyphenyl porphyrin solution is obtained. After an activatingagent and copper 4-carboxyphenyl porphyrin are mixed, the amino-rich stent material is put into a mixed solution for a reaction, taken out, flushed and sterilized. The surface of the blood vessel stent material is modified with copper 4-carboxyphenyl porphyrin, in this way, good biological compatibility is realized, repairing of endothelial cells can be promoted, and excessive proliferation of smooth muscle cells can be inhibited.

The present disclosure provides antibodies that specifically bind to human FAM19A5 and compositions comprising such antibodies. Also provided herein are methods for treating fibrosis or cancer using the anti-FAM19A5 antibodies.

The invention discloses application of small-molecule oligopeptide in preparing a product for treating acnes. The small-molecule oligopeptide disclosed by the invention is bFGF (basic fibroblalst growth factor) derived degraded oligopeptide consisting of 8 amino acid residues, and the amino acid sequence of the small-molecule oligopeptide is LQLQAEER. The invention finds that the small-molecule oligopeptide is capable of inhibiting excessive proliferation of sebaceous gland and reducing grease secretion of skin, in addition, is high in stability, small in toxicity and side effect, applicable to massive people, good in percutaneous permeability and capable of continuously acting on treatment parts, therefore, can be applied to antiacne aspects, particularly can be used for treating acnes caused by variation of hormonal levels in the puberty period and the gestation period.

The invention relates to the field of interventional medical devices, and especially relates to a surface modification method for improving the corrosion resistance of a magnesium alloy intravascularstent. The method is suitable for a novel dual-drug degradable magnesium alloy intravascular stent for treating intraluminal stenosis, carrying a smooth muscle proliferation inhibitor and promoting endothelialization. The method is characterized in that a drug coating with an endothelialization promoting function is prepared on a magnesium alloy stent to accelerate the endothelialization process after stent implantation and improve the service environment of the stent, so the corrosion resistance of the magnesium alloy intravascular stent is improved. The magnesium alloy intravascular stent carries a drug for inhibiting intimal hypertrophy, and also carries a drug for promoting endothelialization. The stent can realize rapid endothelial regeneration of damaged parts through the action of the drug for promoting endothelialization after being implanted into a diseased blood vessel, so the service environment of the magnesium alloy stent is improved, and the corrosion resistance of the degradable magnesium alloy intravascular stent is improved.

The present invention pertains to a monoclonal antibody, or an antibody fragment thereof, that binds specifically to human growth arrest-specific 6 (hGas6) and binds to at least one amino acid residue among the 314th, 315th, and 316th amino acid residues of human Gas6. The present invention also pertains to: a nucleic acid containing a base sequence that codes for the antibody or the antibody fragment; a transformed cell containing a vector that contains the nucleic acid; a method for producing the antibody or the antibody fragment; reagents for detecting or measuring Gas6 that contain the antibody or the antibody fragment; therapeutic or diagnostic agents for Gas6-related diseases that contain the antibody or the antibody fragment as an active ingredient; and a use of the antibody or the antibody fragment for producing the therapeutic or diagnostic agents for Gas6-related diseases.

The invention provides application of gensenoside C-K and pharmacologically acceptable solvates or hydrates of the gensenoside C-K to preparing medicines for treating psoriasis, a medicine box and a medicine composition with the gensenoside C-K for treating the psoriasis and a method for preparing the medicine composition.

The invention belongs to the technical field of environmental protection, and discloses an environmentally-friendly technology for treating xanthan gum fermentation wastewater. Biological preparationsare used in the invention, and include Paracoccus denitrificans, Clostridium perfringens and Halomonas elogata. The technology is simple to operate, and can thoroughly degrade pollutants such as ammonia nitrogen quickly and efficiently.