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Key protein identification method and system based on protein node characteristics

An identification method and identification system technology, applied in proteomics, biological systems, genomics, etc., can solve the problems of high cost, time-consuming, low recognition efficiency and accuracy of key proteins, and achieve high cost and long time-consuming solutions , the effect of improving the recognition accuracy

Pending Publication Date: 2020-06-19
LANZHOU UNIVERSITY OF TECHNOLOGY
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Problems solved by technology

[0005] The purpose of the present invention is to provide a key protein identification method and system based on protein node characteristics to solve the problems of high cost, time-consuming, low identification efficiency and low accuracy of identifying key proteins using existing biomedical experimental methods

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  • Key protein identification method and system based on protein node characteristics
  • Key protein identification method and system based on protein node characteristics
  • Key protein identification method and system based on protein node characteristics

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Embodiment Construction

[0051] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0052] The purpose of the present invention is to provide a key protein identification method and system based on protein node characteristics to solve the problems of high cost, time-consuming, low identification efficiency and low accuracy of identification of key proteins using existing biomedical experimental methods.

[0053] In order to make the above objects, features and advantages of the present invention more comprehensible, the present invention will...

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Abstract

The invention discloses a key protein identification method and system based on protein node characteristics. The method comprises the following steps: firstly, establishing a protein interaction network and calculating the comprehensive performance of all proteins in the network; sorting all the proteins according to the comprehensive performance and outputting a sorting result; and evaluating the sorting result by adopting a sorting and screening method, and identifying the key protein. Compared with the prior art, local and global topological characteristics of a single node in the whole network are considered, and the structural characteristics of the nodes and the neighbor nodes of the nodes in the compound are also considered, so that the influence of data noise of a single data source on the prediction accuracy can be effectively reduced, the recognition accuracy of the key proteins in the protein interaction network can be remarkably improved, a large number of key proteins canbe predicted, the recognition efficiency of the key proteins is remarkably improved, and the problems of high cost and long consumed time of a biological experiment method are solved.

Description

technical field [0001] The invention relates to the technical field of system bioinformatics, in particular to a key protein identification method and system based on protein node characteristics. Background technique [0002] Protein is an essential component of all cell and tissue structures, and the most important material basis for life activities. Not every protein in a cell is equally important, but different proteins have different importance to life activities. Usually those proteins that cause the loss of relevant biological functions after being deleted and cause the organism to fail to survive or cause disease are called key proteins. The identification of key proteins can provide valuable information for biology and medicine at the system level, especially in disease diagnosis and treatment, drug target design, and determination of the minimum genome in synthetic biology (that is, including all key genes of a species) There are important application prospects. ...

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Application Information

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IPC IPC(8): G16B20/00G16B5/00G16B15/20
CPCG16B20/00G16B5/00G16B15/20
Inventor 卢鹏丽蔚京娟董晨陈玮栾睿张芝铷
Owner LANZHOU UNIVERSITY OF TECHNOLOGY
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