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Application of atractylodes macrocephala polysaccharide in preparation of drug for preventing and treating ulcerative colitis

A technology of ulcerative colitis and Atractylodes polysaccharides, applied in the direction of drug combination, antipyretics, anti-inflammatory agents, etc., to achieve the effect of improving blood in the stool, improving the pathological structure of the colon, and increasing body weight

Pending Publication Date: 2020-08-07
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report about the application of Atractylodes macrocephala polysaccharide in the prevention and treatment of ulcerative colitis.

Method used

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  • Application of atractylodes macrocephala polysaccharide in preparation of drug for preventing and treating ulcerative colitis
  • Application of atractylodes macrocephala polysaccharide in preparation of drug for preventing and treating ulcerative colitis
  • Application of atractylodes macrocephala polysaccharide in preparation of drug for preventing and treating ulcerative colitis

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Experimental program
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Embodiment 1

[0040] The preparation of embodiment 1 Atractylodes macrocephala polysaccharide

[0041] Take 1000g of raw Atractylodes macrocephala, powder it, and pass through a No. 5 sieve. Degrease the powder twice with petroleum ether, add 2L of petroleum ether each time, let it stand at room temperature for 24h, and pour off the supernatant. The residue was placed on a tray, and the petroleum ether was evaporated to dryness at room temperature. Add ethanol (99.7%) to continue degreasing 2 times, add 2L of ethanol each time, heat to reflux for 2h, and pour off the supernatant. The residue was placed on a tray, and the ethanol was evaporated to dryness at room temperature. Add 6 times the amount of pure water to the degreased Atractylodes macrocephala sample, pre-soak for 8 hours, heat and reflux for 2 hours, filter, repeat the extraction 3 times, combine the extracts and centrifuge to remove the precipitate, and the supernatant is concentrated to a certain volume under vacuum. Add 95%...

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Abstract

The invention provides the application of atractylodes macrocephala polysaccharide in preparation of a drug for preventing and treating ulcerative colitis. Experimental results show that the atractylodes macrocephala polysaccharide can increase the weight and the colon length of a colitis mouse, improve the hematochezia condition and the fecal form of the colitis mouse and improve the colon pathological structure of the colitis mouse, can be used as a potential drug for preventing and treating ulcerative colitis, and provides a new drug selection for clinic.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to the application of Atractylodes macrocephala polysaccharide in the preparation of medicines for preventing and treating ulcerative colitis. Background technique [0002] Inflammatory bowel disease (Inflammatory Bowel Disease, IBD), also known as enteritis, is a group of recurrent inflammatory bowel diseases. Inflammatory bowel disease mainly includes two types: Crohn's disease (CD) and ulcerative colitis (UC). In developed countries, the incidence of IBD has reached 1 / 1000. In China, the total number of cases of inflammatory bowel disease in the past ten years is about 350,000. It is worth noting that the number of patients with this disease is increasing year by year. Compared with the previous 10 years, the total number of cases of inflammatory bowel disease has increased by more than 24 times, and the number of patients with Crohn's disease has even increased by more than 15 times. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P1/00A61P29/00
CPCA61K31/715A61P1/00A61P29/00
Inventor 彭成冯五文敖慧王晶张世洋
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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