A kind of composite hydrogel wound dressing and preparation method thereof

Abstract

The invention provides a composite hydrogel wound dressing and a preparation method thereof, which is based on aminated collagen and oxidized sodium alginate, and is loaded with two polypeptides of polymyxin B sulfate and bacitracin Antibiotics, AC / OSA‑PB composite hydrogel dressings are prepared by Schiff base reaction, the preparation method of the present invention is simple to operate, and has low requirements on reaction conditions, and can be gelled in a short time, which is beneficial to large-scale production, and the obtained The wound dressing not only has a good bactericidal effect, but also can maximize the HSF cell migration rate and HSF cell proliferation rate, has an excellent ability to promote wound healing, and also has mechanical properties and mechanical properties suitable for skin wounds.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, in particular to a composite hydrogel wound dressing and a preparation method thereof. Background technique [0002] Skin wound repair is one of the major challenges facing the medical field. According to statistics from the World Health Organization, millions of people around the world suffer from skin injuries every year, and about 180,000 of them die from burns rather than fatal burns. is the main causative factor. Large-scale non-lethal wounds destroy the normal physiological function of the skin. Without timely and effective treatment, the wound is likely to be invaded by microorganisms and become infected, thereby delaying the healing of the wound, and in severe cases, it will be life-threatening. Therefore, effective control of wound infection and rapid wound healing are important ways to reduce patient mortality. Full-thickness skin wound tissue undergoes a complex process ...

AI Technical Summary

Problems solved by technology

The prepared fish skin collagen-chitosan composite alginate hydrogel dressing can effectively shorten the healing period, eliminate wound inflammation, and inhibit scar formation, and has a good prospect and application direction in wound care. There are many defects, as follows: (1) Sodium alginate, fish skin collagen, polyvinyl alcohol and glycerin are used to prepare the gel solution, polyvinyl alcohol is an organic compound, which is harmful to the human body; Place it under the condition of ℃ for 2 hours, and then add the cross-linking agent prepared by chitosan and anhydrous calcium chloride to carry out the cross-linking reaction. The whole cross-linking process usually takes several hours to realize gelation. production efficiency, and the cross-linking steps are cumbersome, which increases uncertainties; (3) Compared with other hydrogels, Ca 2+ The hydrogel prepared by cross-linking has the characteristics of unevenness, hardness and brittleness, which is not conducive to the comfort of the wound

In addition, the incorporation of calcium ion impurities has a certain impact on wound healing; (4) chitosan, as a natural antibacterial agent, has poor antibacterial effect compared with antibiotics, and the antibacterial concentration and antibacterial concentration of chitosan The performance is closely related to its preparation process, molecular weight and molecular structure. At present, chitosan is mainly obtained through extraction methods, which requires high control of raw materials and production processes, making it difficult to grasp the production stability of chitosan, which also leads to The antibacterial effects of chitosan products on the market are uneven, which increases the trouble of screening chitosan

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