Composition and application for alleviating degenerative neuropathy

A neuropathy and composition technology, applied in the field of compositions for relieving degenerative neuropathy, can solve problems such as poor curative effect, obvious side effects, unclear PD pathogenesis, etc. The effect of distribution and shape

Active Publication Date: 2022-06-07
SICHUAN AGRI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pathogenesis of PD is not clear. Studies have shown that the etiology of PD interacts with factors such as the environment, genetic factors, immune inflammation, and internal environment disturbances in the brain. However, the most concerned is the impact of oxidative stress.
The current drugs for alleviating PD symptoms are not effective or have obvious side effects, so alleviating and improving PD symptoms has important clinical significance

Method used

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  • Composition and application for alleviating degenerative neuropathy
  • Composition and application for alleviating degenerative neuropathy
  • Composition and application for alleviating degenerative neuropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A composition comprising the following components in parts by weight: 5 parts of nano-selenium, 20 parts of glucose, 10 parts of sorbitol, 120 parts of glycine, the average particle diameter of nano-selenium is 50nm, the composition of this embodiment 2 can improve Motor dysfunction in Parkinson's model mice improves neurons in the substantia nigra pars compacta.

Embodiment 2

[0032] A composition comprising the following components in parts by weight: 2.5 parts of nano-selenium, 15 parts of glucose, 7.5 parts of sorbitol, and 100 parts of glycine. The average particle diameter of nano-selenium is 50nm.

[0033] The composition of the invention can be used to prepare a food additive for alleviating degenerative neuropathy, and the degenerative neuropathy is Parkinson's disease. The oral dosage form formed by the composition and pharmaceutically acceptable excipients can be used to alleviate degenerative neuropathy, and the excipients are made into any oral dosage form in granules, capsules, concentrated pills or tablets , and a single dose of 0.1mg / kg (based on body weight).

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Abstract

The invention discloses a composition for alleviating degenerative neuropathy and its application. The composition comprises the following components in parts by weight: 2.5-5 parts of nano-selenium, 15-20 parts of glucose, and 7.5-10 parts of sorbitol , 100-120 parts of glycine; wherein, the particle size of the nano-selenium is 50±2nm. The composition of the present invention can improve the motor dysfunction, substantia nigra pars compacta neurons and tyrosine hydroxylase positive neurons of the MPTP-induced Parkinson's disease mouse model, increase the activity of SOD and GSH-PX in the brain and reduce the MDA levels.

Description

technical field [0001] The invention relates to a composition, in particular to a composition and application for alleviating degenerative neuropathy. Background technique [0002] Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. The main clinical features of PD are divided into motor symptoms and non-motor symptoms. Motor symptoms include resting tremor, muscle rigidity, bradykinesia, decreased exercise volume, uncoordinated posture and steps, etc.; non-motor symptoms include sleep disturbance, constipation, hyposmia, etc. . The main pathological features of PD are the degeneration and death of dopaminergic neurons in the substantia nigra compacta of the midbrain, and the degeneration of the substantia nigra-striatum pathway, resulting in a decrease in dopamine content in the striatum. Through pathological analysis, the cytoplasm of residual neurons in the substantia nigra can be seen. There are eosinophilic inclusion...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/04A61P25/28A61P25/16A23L33/16A23L33/125A23L33/175A23K20/163A23K20/20A23K20/142A61K31/7004A61K31/047A61K31/198
CPCA61K33/04A61K31/7004A61K31/047A61K31/198A61P25/28A61P25/16A23L33/16A23L33/125A23L33/175A23K20/30A23K20/163A23K20/142A23V2002/00A61K2300/00A23V2250/1626A23V2250/61A23V2250/642A23V2250/0622A23V2200/322
Inventor 胡延春洪作鹏曾朝蓉章亦武蔡菊岳冬
Owner SICHUAN AGRI UNIV
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