33results about How to "Lower MDA levels" patented technology

The invention discloses a formula feed for the pig fattening period.The formula feed is prepared from, by weight, 40-50 parts of fermented corn germ meal, 20-30 parts of rice bran, 15-20 parts of drydistiller's grains, 10-15 parts of rapeseed cake, 10-15 parts of bean cake, 12-16 parts of a Chinese herbal medicine preparation, 5-8 parts of fish meal, 4-6parts of meat and bone meal, 7-10 parts ofcorn oil, 1-2 parts of salt, 1-2 parts of green tea powder, 0.8-1.2 parts of fermented polysaccharides and a trace amount of additives.The invention further disclosesa preparation method of the formula feed for the pig fattening period.Accordingly, the fermented corn germ meal serves as the main feed material, the fermented corn germ meal has the functions of achieving digestion and absorption easily and promoting growth, the surface of the feed is wrapped with a layer of Chinese herbal medicine preparation,the obtained feed has the effects of achieving the anti-bacterial property, diminishinginflammation, enhancing immunity, maintaining the balance of gastrointestinal microflora and the like, the nutritional requirements of fattening pigs in the growth period can be fully met, the fattening pigs can grow rapidly, the meat quality is obviously improved, and the disease resistance is high.

The invention relates to novel pharmacologic action of mangiferin, i.e., effects of mangiferin on preventing and treating diabetic encephalopathy. Mangiferin can obviously improve cognitive impairment caused by diabetes, remarkably reduce the level of advanced glycation endproducts (AGF) in the brain and expression of the acceptor RAGE thereof, substantially enhance activity and expression of glyoxalase 1 (Glo-1) in the brain, remarkably reduce the level of interleukin 1-beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) in the brain, substantially improve the level of reduced glutathione (GSH) in the brain, remarkably reduce the level of malonaldehyde (MDA) in the brain, substantially improve the activity of superoxide dismutase (SOD) and the level of GSH in serum and substantially reduce the level of MDA in the serum. Mangiferin can be used for preventing and treating diabetic complications like diabetic encephalopathy.

The invention discloses an age-defying drug, made by mixing well 0.3-99.7 parts by weight of industrial hemp seed extract and 99.7-0.3 part by weight of industrial cannabine. Experiments prove that this drug composition can prolong half survival time, average life and highest life of fruit fly to different degrees, can significantly improve SOD and GSH-PX activity in brain, heart and liver of a model mouse and very significantly lower MDA level in brain, heart and liver tissues. The drug composition can improve body immunity, clear oxygen radicals in body, inhibit lipid peroxidation and defy age, can prevent and treat diseases related to free radicals and has a promising application prospect.

The invention relates to the field of medicines, and particularly relates to an application of notoginsenoside R1. Experiments prove that NTR1 can be used for improving the cognition, learning and memory capabilities of an APP / PS1 transgenic AD mouse, restoring the intracerebral ChAT level of the mouse, reducing the intracerebral malondialdehyde level, and improving the mitochondrial function of the AD mouse by improving the CcO activity. In addition, the NTR1 also can be used for increasing the IDE level so as to promote degradation of A beta and inhibit the accumulation of the A beta. Therefore, the invention further provides the application of the notoginsenoside R1 to preparation of a medicament for treating an alzheimer disease. Moreover, experiments prove that the notoginsenoside R1 causes no influences to cell viability within a concentration range of 0-500 micromoles, so the notoginsenoside R1 is proved to be safe in medication.

The invention discloses an application of dioscin to preparation of medicines for treating Alzheimer's diseases. The Morris water maze testing result shows that a dioscin administration group can shorten the escaping latency period, prolong original platform quadrant residence time and increase the number of times of passing through a platform, which indicates that the dioscin can significantly improve the spatial learning and memorizing capacity of AD mice; the gait analysis result indicates that the dioscin can significantly increase the gait indexes of the AD mice, and strengthen the physical strength of the AD mice, so that the movement velocity of the AD mice is accelerated, the stride frequency is increased, the stepping length is increased and the duty cycle can be significantly shortened; the dioscin can significantly reduce the MDA level in hippocampal tissue of the AD mice, increase the GSH level and the SOD level, and improve oxidative damage of brain tissue of the AD mice;and the dioscin can restrain AchE activity of the hippocampal tissue, increase ChAT level, influence a cholinergic system, obviously improve the pathology structure of the brain tissue of the AD miceand ultrastructural damage of nerve cells. The dioscin can be used as a single effective component to be prepared into medicines, and can be combined with other medicines for preparing a compound preparation.

The present invention discloses a Chinese medicine injection for curing acute cerebral hemorrhage. It is made of (by weight ratio) antelope horn 1-70, moutan root bark 4-164, acorus root 2-60 and gardenia fruit 10-120 as raw material. Said invention also discloses its preparation method, and said injection possesses the good therapeutic effect.

The invention discloses applications of lactobacillus kefir M11 in bacteriostasis and in the treatment of type 2 diabetes mellitus as an active ingredient of medicament. The invention solves the problems of low surface hydrophobicity and poor bacteriostasis ability of the existing lactic acid bacteria. The lactobacillus kefiriM11 of the invention has an obvious inhibitory effect on escherichia coli and staphylococcus aureus, with a good bacteriostatic effect. According to the invention, the lactobacillus kefir iM11 and a bacterial preparation thereof have excellent surface hydrophobicity and cohesion and a good adhesion ability to the intestinal tract, thus realizing a good blood sugar regulation ability in the application of type 2 diabetes mellitus. The invention has an obvious effect onalleviating symptoms of type 2 diabetes mellitus.

The invention relates to a drug for treating diabetes mellitus and a preparation method for the drug. The drug is prepared from the following raw materials in parts by weight: 27-33 parts of folium mori, 17-23 parts of bamboo leaves, 17-23 parts of purslane, 12-18 parts of dendrobes, 7-13 parts of Chinese yams and 2-8 parts of cordyceps sinensis. The drug disclosed by the invention can treat the diabetes mellitus with a remarkable curative effect, is small in toxic or side effects and free of complications, less in treatment cost, and has the advantages of being good in treatment effect, simple and convenient in preparation method.

The invention belongs to the technical fields of tree secondary metabolism active ingredients and natural medicines, and particularly relates to a method for preparing macranthoin G by taking medicinal tree seed eucommia ulmoides as a raw material, and use of the macranthoin G in preparation of a neuroprotective medicine. The macranthoin G is prepared from eucommia ulmoides tree plant materials as raw materials in manners of drawing, extracting and separating. Themacranthoin G is simple in preparation technology, low in cost, short in cycle and high in yield. An experiment proves that themacranthoin G plays a significant protection role on a model cell injury, and indicates that the macranthoin G can be applied to preparation of the neuroprotective medicine, so as to prevent and treat various neurodegenerative diseases.

The invention discloses novel applications of Jingzhaotoxin, and particularly relates to an application of Jingzhaotoxin in a medicament for treating and / or preventing cerebrovascular disorder (apoplexy) and an application of Jingzhaotoxin in a medicament for preventing and / or treating nerve injuries. According to the invention, the Jingzhaotoxin has a remarkable repairing effect on nerve injuries, such as anticoagulation, free radical removal [superoxide dismutase (SOD) activity reinforcement, malondialdehyde (MDA) level reduction, inflammation cyclooxygenase-2 (COX-2) transcriptional level reduction and other applications are included], ischemic stroke symptom relief, cerebral infarction area reduction and the like.

The invention discloses novel applications of Jingzhaotoxin, and particularly relates to an application of Jingzhaotoxin in a medicament for treating and / or preventing cerebrovascular disorder (apoplexy) and an application of Jingzhaotoxin in a medicament for preventing and / or treating nerve injuries. According to the invention, the Jingzhaotoxin has a remarkable repairing effect on nerve injuries, such as anticoagulation, free radical removal [superoxide dismutase (SOD) activity reinforcement, malondialdehyde (MDA) level reduction, inflammation cyclooxygenase-2 (COX-2) transcriptional level reduction and other applications are included], ischemic stroke symptom relief, cerebral infarction area reduction and the like.

The invention belongs to the field of biomedical research, in particular to the application of NADPH and vitamin E in combination for preparing a medicine for preventing or treating liver damage. NADPH and vitamin E can play a synergistic effect within a certain dose range, and have a good protective effect on liver damage caused by carbon tetrachloride, not only can significantly reduce aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphate Enzyme (ALP) and total bilirubin (TB) content, and can increase the content of ATP in hepatocytes, reduce the levels of MDA in hepatocytes and serum, increase the levels of SOD and GSH in hepatocytes and serum, and increase the levels of SOD and GSH in hepatocytes. CAT level. It was also proved by cell experiments that the combination of NADPH and vitamin E could significantly reduce the decrease in the survival rate of liver cells in the liver injury model induced by CCl4, thereby playing a role in preventing or treating liver injury.

The invention discloses a composition for alleviating degenerative neuropathy and its application. The composition comprises the following components in parts by weight: 2.5-5 parts of nano-selenium, 15-20 parts of glucose, and 7.5-10 parts of sorbitol , 100-120 parts of glycine; wherein, the particle size of the nano-selenium is 50±2nm. The composition of the present invention can improve the motor dysfunction, substantia nigra pars compacta neurons and tyrosine hydroxylase positive neurons of the MPTP-induced Parkinson's disease mouse model, increase the activity of SOD and GSH-PX in the brain and reduce the MDA levels.

The invention relates to the field of natural Chinese herbal protein, in particular to application of angelica protein to preparation of a medicine for protecting against acute liver damage. The N-terminal sequence of the angelica protein is GIQKTEVEAPSTVSA. The angelica protein has a significant proliferative effect on normal liver cells L-02, and at the dosage of 0.5mg / mL, the proliferation rateof L-02 cells can reach 163.114%. The angelica protein is applied to preparation of the medicine for preventing the liver damage, can significantly improve the CAT, GST and T-AOC activity of the liver of a damaged mouse and significantly reduce the MDA level of the liver, significantly improves the liver cell necrosis of the liver of the damaged mouse, thereby significantly reduces the blood ALTand AST activity and liver indexes of the damaged mouse to the normal group levels basically, and thus significantly reduces damage of CCl4 to the mouse liver.

The invention discloses a composition for regulating skin collagen metabolism and its application. The composition is composed of modified cyclodextrin and an anti-aging regulator. The preparation of modified cyclodextrin is based on alcohol on β-cyclodextrin Hydroxyl and stearic acid are obtained by esterification reaction under the action of an acid catalyst, and a long chain of hydrophobic fat is introduced into the β-cyclodextrin. The modified β-cyclodextrin not only has hydrophilicity but also has certain Lipophilicity, the formation of more hydrophobic holes in the modified cyclodextrin makes it easier to form inclusion complexes with guest molecule anti-aging regulators, which can be applied to cosmetics to improve the compatibility of inclusion complexes with other components. It is easier to emulsify to form a uniform emulsion. In addition, the form of inclusion compound ensures the stability of the anti-aging regulator and effectively inhibits the photolysis of the anti-aging regulator. When applied to cosmetics, it avoids secondary damage to the skin , maintain the thickness of the dermis and the content of total skin collagen, and delay skin aging.