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Application of laminarin in preparation of medicaments or cosmetics for adjusting metabolism of collagen of skin

A technology of laminarin and collagen, which is applied to the new application of laminarin, the application field of laminarin in the preparation of drugs or cosmetics that regulate skin collagen metabolism, and can solve the problems of anti-aging skin and no reports

Inactive Publication Date: 2013-06-12
GUANGXI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Many studies have shown that laminarin has pharmacological activities such as anti-oxidation, anti-radiation, anti-thrombosis, improvement of microcirculation, and protection of vascular endothelial cells. to report

Method used

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  • Application of laminarin in preparation of medicaments or cosmetics for adjusting metabolism of collagen of skin
  • Application of laminarin in preparation of medicaments or cosmetics for adjusting metabolism of collagen of skin
  • Application of laminarin in preparation of medicaments or cosmetics for adjusting metabolism of collagen of skin

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Experimental program
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Effect test

Embodiment Construction

[0010] The inventor confirmed that laminarin has a regulating effect on skin collagen metabolism by establishing an aging animal model. The specific experimental research is as follows:

[0011] 1. Experimental content

[0012] (1) Extraction of laminarin

[0013] Laminaria polysaccharide is obtained from inventors’ references (Xie L, Chen MH, Li J, et al.Antithrombotic Effect of a polysaccharide fraction from laminaria japonica from the south china sea[J].Phytotherapy Research,2011,25(9):1362- 6.) Self-extraction, enzymatic hydrolysis, water bath, alcohol precipitation, centrifugation and other steps to obtain laminarin, the sugar content is 71%, and the sulfate content is 83.28mg·g -1 The polysaccharide components detected by HPLC were glucose (5.05%), mannose (25.10%), rhamnose (7.37%), galactose (8.46%), and xylose (54.02%).

[0014] (2) Observe the effect of laminarin on photoaging skin by intraperitoneal injection

[0015] ①Establishment, grouping and administration o...

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Abstract

The invention discloses an application of laminarin in preparation of medicaments or cosmetics for adjusting metabolism of collagen of skin. Experimental study proves that laminarin can obviously reduce the MDA level of a skin tissue under ultraviolet radiation, increase the contents of SOD, GSH-Px and CAT in the skin tissue and improve the antioxidant capacity of the skin tissue, can obviously thicken a dermis layer of the skin under the ultraviolet radiation and increase the content of total collagen of the skin, can obviously increase the content of I-type collagen mRNA (messenger ribonucleic acid) of the skin tissue, and can also reduce the activity of the collagen by inhibiting the content of the MMP (matrix metallo proteinase)-1mRNA of the skin tissue under the ultraviolet radiation, so that the degradation of the collagen is reduced, and aging of the skin is slowed down under the ultraviolet radiation.

Description

technical field [0001] The invention belongs to the technical field of laminarin, and in particular relates to a new application of laminarin, in particular to the application of laminarin in the preparation of drugs or cosmetics for regulating skin collagen metabolism. Background technique [0002] At present, in addition to applying minimally invasive techniques to carry out various treatments in the world, drug therapy and supplementary therapy have also begun to become the main means of anti-aging skin. Some chemical drugs, such as free radical scavengers, cell differentiation inducers, hormones, etc., can regulate collagen metabolism, thereby exerting the effect of delaying skin aging; there are also some traditional Chinese medicine ingredients, such as salidroside, salvia miltiorrhiza, wolfberry, and scutellaria baicalensis extract It also has the effect of repairing skin collagen. These studies are mostly carried out from the aspects of enhancing the body's antioxid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P17/18A61P17/16A61K8/73A61Q19/00A61Q19/08A61Q17/00
Inventor 黎静谢露杨晓梅
Owner GUANGXI MEDICAL UNIVERSITY
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