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A polymer self-healing gel integrating magnetic resonance imaging and photothermal therapy and its preparation and application

A technology of magnetic resonance imaging and photothermal therapy, applied in the field of medical polymer materials, can solve problems such as strong fluidity, refractory degradation, and nerve cell death, and achieve the effect of promoting cartilage repair, tissue repair, and cell growth

Active Publication Date: 2021-03-26
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, traditional magnetic resonance contrast agents are mostly heavy metal complexes or nano-oxides. Although the imaging effect is good and has been used in clinical treatment, there are still various defects. For example, the commonly used heavy metal complexes Gd 3+ It is highly toxic and can even cause brain allergies and nerve cell death; while the commonly used nano-Fe 3 o 4 The particles are small, will flow with the blood in the body, and are difficult to be excreted from the human metabolic system
In addition, contrast agents are mostly injected in the form of solutions, which have strong fluidity, short imaging time, and ineffective effects
Therefore, in order to solve the disadvantages of traditional magnetic resonance contrast agents, such as high toxicity, refractory degradation, and short diagnosis time, it is necessary to develop a safe, degradable, and long-term imaging medical material for magnetic resonance imaging.

Method used

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  • A polymer self-healing gel integrating magnetic resonance imaging and photothermal therapy and its preparation and application
  • A polymer self-healing gel integrating magnetic resonance imaging and photothermal therapy and its preparation and application
  • A polymer self-healing gel integrating magnetic resonance imaging and photothermal therapy and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] (1) Weigh 2g of carboxymethyl chitosan powder and dissolve it in 100mL of deionized water, stir magnetically at room temperature for 1 hour until it dissolves evenly, and store it in a refrigerator at 4°C for later use. Weigh 1.1 g of chitosan and dissolve it in 100 mL of dimethyl sulfoxide (chemically pure), stir magnetically at room temperature for 1 h until it dissolves evenly, and store it in a refrigerator at 4°C for later use.

[0055] (2) Weigh 2.2 g of p-aldehyde benzoic acid and dissolve it in 20 mL of dimethyl sulfoxide (chemically pure), stir magnetically at room temperature for 0.5 h until it dissolves evenly, and store it in a refrigerator at 4°C for later use. Weigh 0.66 g of 4-dimethylaminopyridine (DMAP) and dissolve it in 100 mL of dimethyl sulfoxide (chemically pure), stir magnetically at room temperature for 0.5 h until it dissolves evenly, and store it in a refrigerator at 4°C for later use. Weigh 1.1 g of dicyclohexylcarbodiimide (DCC) and dissolve ...

Embodiment 2

[0065] (1) Weigh 8g of carboxymethyl chitosan powder and dissolve it in 100mL of deionized water, stir magnetically at room temperature for 5 hours until it dissolves evenly, and store it in a refrigerator at 4°C for later use. Weigh 5.5g chitosan and dissolve it in 100mL dimethyl sulfoxide (chemically pure), stir magnetically at room temperature for 6h until it dissolves evenly, and store it in a refrigerator at 4°C for later use.

[0066] (2) Weigh 6.6 g of p-aldehyde benzoic acid and dissolve it in 20 mL of dimethyl sulfoxide (chemically pure), stir magnetically at room temperature for 2 h until the solution is uniform, and store in a refrigerator at 4°C for later use. Weigh 1.32 g of 4-dimethylaminopyridine (DMAP) and dissolve it in 100 mL of dimethyl sulfoxide (chemically pure), stir magnetically at room temperature for 2 h until it dissolves evenly, and store it in a refrigerator at 4°C for later use. Weigh 3.85 g of dicyclohexylcarbodiimide (DCC) and dissolve it in 10 m...

Embodiment 3

[0077] (1) Weigh 6g of carboxymethyl chitosan powder and dissolve it in 100mL of deionized water, stir magnetically at room temperature for 4 hours until it dissolves evenly, and store it in a refrigerator at 4°C for later use. Weigh 2.5g chitosan and dissolve it in 100mL dimethyl sulfoxide (chemically pure), stir magnetically at room temperature for 2h until it dissolves evenly, and store it in a refrigerator at 4°C for later use.

[0078] (2) Weigh 2.5 g of p-aldehyde benzoic acid and dissolve it in 20 mL of dimethyl sulfoxide (chemically pure), stir magnetically at room temperature for 1 h until the solution is uniform, and store in a refrigerator at 4°C for later use. Weigh 0.8 g of 4-dimethylaminopyridine (DMAP) and dissolve it in 100 mL of dimethyl sulfoxide (chemically pure), stir magnetically at room temperature for 0.5 h until it dissolves evenly, and store it in a refrigerator at 4°C for later use. Weigh 1.68 g of dicyclohexylcarbodiimide (DCC) and dissolve it in 10 ...

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Abstract

The invention discloses preparation and application of a macromolecule self-healing gel integrating magnetic resonance imaging and photothermal therapy. According to the invention, Mn < 2 + > with biological activity is used as a chelating site, is adopted to form a three-dimensional network structure with a natural polymer, and at the same time, nanometer gold rods with photothermal effect is doped, so that the safe and degradable medical hydrogel capable of promoting cell growth and damaged tissue repair and having functions of magnetic resonance imaging diagnosis and photothermal treatmentis developed, and the double effects of diagnosis and treatment can be achieved through one-time injection. Meanwhile, in combination with the self-healing function, the composite hydrogel has considerable development prospects and potential medical value in the fields of tissue engineering, lesion diagnosis, fixed-point monitoring and imaging, photothermal therapy and the like.

Description

technical field [0001] The invention belongs to the field of medical polymer materials, and in particular relates to a polymer self-healing gel integrating magnetic resonance imaging and photothermal therapy, as well as its preparation and application. Background technique [0002] Magnetic resonance imaging is a kind of emission tomography, which uses magnetic resonance phenomena to obtain electromagnetic signals from the human body, thereby reconstructing digital images of the human body system. It has remarkable results in the diagnosis of syringomyelia, cranial neuropathy, brain tumor, angiography, and soft tissue injury. [0003] At present, traditional magnetic resonance contrast agents are mostly heavy metal complexes or nano-oxides. Although the imaging effect is good and has been used in clinical treatment, there are still various defects. For example, the commonly used heavy metal complexes Gd 3+ It is highly toxic and can even cause brain allergies and nerve cell...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K33/32A61K9/06A61K47/36A61P25/00A61P19/04A61K49/12A61K49/18
CPCA61K9/06A61K33/32A61K41/0052A61K47/36A61K49/126A61K49/1803A61P19/04A61P25/00A61K2300/00
Inventor 蒋刚彪朱水容刘斌胡甜刘步宁庞卯
Owner SOUTH CHINA AGRI UNIV
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