A ligand-modified myricetin liposome particle size control device

Abstract

The invention provides a ligand-modified myricetin liposome particle size control device, which includes a reactor, an air pump is fixedly connected to the right side of the support, a rack plate is fixedly connected to the right side of the piston rod, and the inner top wall of the support An incomplete gear is installed on the upper rotation, and a limit piece corresponding to the incomplete gear is movably inserted on the left side of the drum. The top of the lifting plate is respectively connected with the incomplete gear and the drum through the drive assembly. The fixed leveling has a steel wire rope inserted inside the reactor. During the crushing process, the solution is constantly oscillating, which makes the steel wire rope vibrate. The steel wire rope drives the lifting plate to reciprocate through the movable plate, and the piston rod reciprocates under the pull of the incomplete gear and the tension spring, and the foam generated during ultrasonic crushing is sucked through the pump. into the collection box to avoid foam affecting the crushing power, thereby ensuring the size uniformity of myricetin liposome particles after ultrasonic crushing.

Description

technical field [0001] The invention belongs to the technical field of myricetin liposome preparation, in particular to a ligand-modified myricetin liposome particle size control device. Background technique [0002] Myricetin, also known as myricetin, is widely found in a variety of natural plants and has a wide range of pharmacological activities. It also has anti-inflammatory, anti-tumor, analgesic, liver-protecting and hypoglycemic effects. Anti-oxidation and cholesterol-lowering effects can be added to cosmetics as antioxidants, and can also be used as health products. Therefore, myricetin has good development and application potential. [0003] The preparation process of ligand-modified myricetin liposomes is as follows: Weigh soybean lecithin, cholesterol, myricetin and DSPE-PEG2000-RGD, add absolute ethanol to fully dissolve the four, then evaporate to form a film, add PBS solution to dissolve , so that the membrane is dissolved and dispersed and fully hydrated, ult...

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Problems solved by technology

[0003] The preparation process of ligand-modified myricetin liposomes is as follows: Weigh soybean lecithin, cholesterol, myricetin and DSPE-PEG2000-RGD, add absolute ethanol to fully dissolve the four, then evaporate to form a film, add PBS solution to dissolve , so that the membrane is dissolved and dispersed and fully hydrated, ultrasonically broken by a cell ultrasonic breaker, filtered through a microporous membrane, and finally formed RGD peptide-modified myricetin liposomes, which will produce a large amount of foam when ultrasonically broken. It affects the crushing power, and finally leads to incomplete crushing, and the particle size of myricetin liposomes varies

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