Large-detection-range multichannel optical fiber SPR microfluidic chip

Abstract

The invention belongs to the field of optical fiber sensing, and particularly relates to a large-detection-range multichannel optical fiber SPR microfluidic chip which comprises a hemispheroid three-core optical fiber end surface area, a hemispheroid three-core optical fiber SPR sensing area, an optical fiber SPR microfluidic chip and a spherical plastic cladding optical fiber SPR sensing area which are connected in sequence, wherein the hemispheroid three-core optical fiber end face area is formed by conducting multiple times of discharging ball melting on one end face of a three-core opticalfiber and then grinding the end face, the hemispheroid three-core optical fiber SPR sensing area and the spherical plastic cladding optical fiber SPR sensing area are welded to the two sides of the optical fiber SPR microfluidic chip respectively; the hemispheroid three-core optical fiber SPR sensing area and the spherical plastic cladding optical fiber SPR sensing area are subjected to electricdischarge heating and melting, and then the thrust is applied to form a ball; with adopting of the multichannel optical fiber SPR microfluidic chip adopts, the total reflection angle can be conveniently controlled, so that the working range of SPR resonance wavelength is changed, and large-detection-range detection is realized.

Description

technical field [0001] The invention belongs to the field of optical fiber sensing, and in particular relates to a multi-channel optical fiber SPR microfluidic chip with a large detection range. Background technique [0002] Fiber-optic surface plasmon resonance (Surface Plasmon Resonance, SPR) sensors have been more and more widely used in the detection of biomolecular interactions, chemical and biological analyte reactions, and so on. The mechanism of SPR is: when the angle or wavelength of the incident light satisfies a certain value, most of the energy of the incident light is converted into the energy of the surface plasmon wave, the energy of the reflected light suddenly drops, and a resonant absorption peak appears on the reflection spectrum. The angle or wavelength of the incident angle is called the SPR resonance angle or resonance wavelength. By accurately measuring the resonance angle or resonance wavelength change, the refractive index change of the metal film su...

AI Technical Summary

Problems solved by technology

In order to improve the detection efficiency of SPR, the microfluidic technology is combined with the optical fiber SPR sensor, so that the optical fiber SPR microfluidic chip has some important characteristics of both microfluidic technology and SPR sensing mechanism. Rapid detection of liquids shortens the reaction time, improves detection efficiency, and lower production costs, which makes fiber optic SPR microfluidic chips more widely used. At present, the combination of microfluidic technology and fiber optic SPR sensors mainly faces a limited detection range. Specifically, because the SPR resonance wavelength is related to the total reflection angle, in order to change the working range of the SPR resonance wavelength, it is usually necessary to bend the side-polished fiber to meet the SPR resonance angle. Due to the characteristics of the fiber size, not only the processing is complicated and difficult, but also The angle that can be changed is also relatively limited; in addition, due to the characteristics of the structure, the existing microfluidic chip can usually only measure liquids with high refractive index or low refractive index, and it is difficult to adapt to liquids with different refractive indices at the same time, and the detection range needs to be further improved.

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