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Pharmaceutical composition for inhibiting pancreatic cancer and pharmaceutical application thereof

A composition and technology for pancreatic cancer, applied in the direction of drug combinations, active ingredients of heterocyclic compounds, antineoplastic drugs, etc., can solve the problems of large liver and kidney toxicity, achieve low dosage, reduce toxic and side effects, and reduce drug resistance sexual effect

Inactive Publication Date: 2021-03-02
GUIZHOU BAIQIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because cantharidin has greater liver and kidney toxicity when used, it is less directly used in clinical practice.

Method used

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  • Pharmaceutical composition for inhibiting pancreatic cancer and pharmaceutical application thereof
  • Pharmaceutical composition for inhibiting pancreatic cancer and pharmaceutical application thereof
  • Pharmaceutical composition for inhibiting pancreatic cancer and pharmaceutical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: the preparation of pharmaceutical composition

[0034] Method 1: Take 5 μM, 10 μM, and 15 μM of sodium cantharidinate respectively, add commonly used pharmaceutical excipients or auxiliary components, and prepare injections, powder injections, tablets, capsules, and granules according to conventional methods.

[0035] Method 2: Take 15 μM sodium cantharidinate and 0.1 μM gemcitabine, mix them evenly, add commonly used pharmaceutical excipients or auxiliary components, and prepare injections, powder injections, tablets, capsules, and granules according to conventional methods.

[0036] Method 3: Take 10 μM sodium cantharidinate and 5 μM gemcitabine, mix them evenly, add commonly used pharmaceutical excipients or auxiliary components, and prepare injections, powder injections, tablets, capsules, and granules according to conventional methods.

[0037] Method 4: Take 5 μM sodium cantharidinate and 10 μM gemcitabine, mix them evenly, add commonly used pharmace...

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Abstract

The invention discloses a pharmaceutical composition for inhibiting pancreatic cancer and a pharmaceutical application thereof. Active ingredients in the pharmaceutical composition contain sodium cantharidate or sodium cantharidate and gemcitabine. The pharmaceutical composition disclosed by the invention has a synergistic anti-pancreatic cancer effect and can promote the apoptosis effect of PANC-1 cells, so that the purpose of treating pancreatic cancer is achieved; under the condition of the same curative effect, the administration dosage is low, the generation of drug resistance is reduced,meanwhile, toxic and side effects are reduced, and the compliance and medication safety of patients are improved.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a pharmaceutical composition for inhibiting pancreatic cancer and its pharmaceutical application. Background technique [0002] Pancreatic cancer is a highly malignant tumor of the digestive tract that is difficult to diagnose and treat. About 90% of them are ductal adenocarcinomas originating from the ductal epithelium. Its morbidity and mortality have increased significantly in recent years, and its 5-year survival rate is <1%. It is one of the malignant tumors with the worst prognosis. In the treatment against pancreatic cancer, despite tremendous efforts in both basic and clinical research, there is still a huge difference in efficacy between the preclinical and clinical stages. Even if patients undergo surgical treatment at an early stage, they usually still have recurrence and metastasis. Therefore, new treatments for this extremely aggressive tumor are urgently need...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/34A61K31/7068A61P35/00
CPCA61K31/34A61K31/7068A61P35/00A61K2300/00
Inventor 张涛涛何莉华彭严
Owner GUIZHOU BAIQIANG PHARMA
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