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Application of compounds in preparation of anti-A6 coxsackie virus medicine

A Coxsackie virus and compound technology, applied in the field of medicine, can solve the problems that there are no research reports on anti-CV-A6, and the virus has no direct killing effect, etc.

Active Publication Date: 2021-03-12
SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sheng Jiehuang et al. (2008) showed that chlorogenic acid has obvious antiviral effect on HSV-1 infection in vitro, and can effectively prevent virus infection, but has no direct killing effect on virus.
However, there is no research report on anti-CV-A6
However, there is no research report on anti-CV-A6
However, there is no research report on anti-CV-A6

Method used

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  • Application of compounds in preparation of anti-A6 coxsackie virus medicine
  • Application of compounds in preparation of anti-A6 coxsackie virus medicine
  • Application of compounds in preparation of anti-A6 coxsackie virus medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Anti-A6 Coxsackievirus Experiment of Artemisinin, Artemisinin, Chlorogenic Acid, Geniposide and Luteolin

[0026] 1.1 Medicinal materials

[0027] The medicinal material of honeysuckle is the dried flower bud of Lonicera japonica Thunb.; the medicinal material of Artemisia annua is the dry aerial part of Artemisia annua L. of the genus Artemisia in the family Compositae; The above medicinal materials were purchased from Jintailian Pharmacy in Tai'an City.

[0028] 1.2 Viruses, cells and animals

[0029] CV-A6 was quoted from the Virus Seed Laboratory of the Institute of Viral Disease Prevention and Control, Chinese Center for Disease Control and Prevention; human rhabdomyoma (Rhabdomyoma, RD) cells were quoted from the Virus Laboratory of the Chinese Institute of Preventive Medicine.

[0030] 1.3 Preparation of solution

[0031] Cell culture medium: MEM medium: fetal bovine serum: double antibody = 89:10:1.

[0032] Cell maintenance solution: MEM medium: f...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to application of compounds arteannuic acid, artemisinin, chlorogenic acid, geniposide and galuteolin in preparationof an anti-A6 coxsackie virus medicine. The biological activity of the anti-A6 coxsackie virus medicine of arteannuic acid, artemisinin, chlorogenic acid, geniposide and galuteolin is found for the first time, the interaction between the anti-A6 coxsackie virus medicine and virus target protein is researched, and the anti-A6 coxsackie virus mechanism of the anti-A6 coxsackie virus medicine is disclosed.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to the application of compounds artemisinic acid, artemisinin, chlorogenic acid, geniposide and luteolin in preparing anti-A6 coxsackievirus drugs. Background technique [0002] Coxsackievirus A6 (CV-A6) is an important category of Coxsackieviruses. Since 2008, CV-A6 has become popular all over the world, gradually spreading from Europe to Asia, and the incidence of hand, foot and mouth disease caused by CV-A6 infection is on the rise. In 2008, CV-A6-positive HFMD first broke out in Finland. In 2009, Taiwan, Spain in 2010, Japan in 2011, Shenzhen, Guangdong, my country in 2013, and France in 2014 successively broke out HFMD caused by CV-A6 infection. disease outbreak. Since 2013, CV-A6 has become one of the main pathogens of HFMD outbreaks. The incidence of hand, foot and mouth disease caused by CV-A6 infection in China is on the rise, and the proportion of patients wi...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61K31/216A61K31/7048A61K31/19A61P31/14
CPCA61K31/216A61K31/7048A61K31/19A61P31/14A61K31/366
Inventor 李菲田景振
Owner SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI
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