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Pharmaceutical composition of guvacine hydrochloride and medical application of pharmaceutical composition

A kind of technology of nor arecoline and composition, applied in the field of chemical medicine, can solve the problems such as anti-breast cancer that no nor arecoline and alfalfa acid have been seen

Inactive Publication Date: 2021-03-26
南京盖斯夫医药科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Norarecoline (CAS NO: 498-96-4) is an alkaloid compound, and alfalfaic acid (CAS NO: 599-07-5) is a pentacyclic triterpenoid compound. A report on the combination of arecoline and alfalfa acid for breast cancer

Method used

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  • Pharmaceutical composition of guvacine hydrochloride and medical application of pharmaceutical composition
  • Pharmaceutical composition of guvacine hydrochloride and medical application of pharmaceutical composition
  • Pharmaceutical composition of guvacine hydrochloride and medical application of pharmaceutical composition

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Experimental program
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Effect test

Embodiment 1

[0013] 1. Experimental materials

[0014] Human breast cancer MCF-7 cells were purchased from ATCC and cultured with RPMI-1640 containing 10% fetal bovine serum at 37°C, 5% CO 2 Routine culture in a cell culture incubator.

[0015] RPMI-1640 medium and fetal bovine serum were purchased from Gibco, USA.

[0016] Norcaline and alfalfaic acid were purchased from Chengdu Desite Biotechnology Co., Ltd., with a purity of ≥98%.

[0017] 2. Experimental methods and results

[0018] Human breast cancer MCF-7 cells in the logarithmic growth phase were digested and resuspended to make a cell suspension, and seeded in a 96-well plate, 1×10 per well 4 1 cell, 200 μL, 37°C, 5% CO 2 After 24 hours of conditioned culture, replace it with RPMI-1640 medium containing different concentrations of different drugs and 10% fetal bovine serum according to Table 1 and continue to culture for 48 hours. At the same time, a blank control group without drugs was set, with 5 duplicate wells for each. ...

Embodiment 2

[0027] A pharmaceutical composition of norarecoline, which is composed of norarecoline and alfalfaic acid in a mass ratio of 2:1. Based on the composition, an anti-breast cancer pharmaceutical preparation is prepared, and the active ingredients are norarecoline and alfalfaic acid in a mass ratio of 2:1.

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Abstract

The invention discloses a pharmaceutical composition of guvacine hydrochloride and medical application of the pharmaceutical composition. The invention finds by research that, in the guvacine hydrochloride-containing pharmaceutical composition different in concentration, the Jin Zhengjun q values of the guvacine hydrochloride and medicagenic acid for jointly inhibiting breast cancer MCF-7 cells are each 1.15 or more, thus indicating that the guvacine hydrochloride and the medicagenic acid have a synergistic effect; and the pharmaceutical composition has the prospect of being developed into theanti-human breast cancer medicine.

Description

technical field [0001] The invention belongs to the field of chemical medicine, and in particular relates to a pharmaceutical composition of norarecoline and its medical application. Background technique [0002] Breast cancer is a common malignant tumor in my country. The incidence rate is increasing day by day and younger, which seriously threatens the health of women. In the treatment of tumors and cancers, if a strong attack can be made on the specific molecular changes of cancer, the treatment effect will be greatly improved. Small molecule drugs can specifically block the signal transduction pathways necessary for tumor growth and proliferation, so as to achieve the purpose of treatment. Moreover, compared with macromolecular drugs, the detection methods of small molecule chemical drugs are relatively simple, and their discovery and modification are much easier. In recent years, the targeted therapy of breast cancer with small molecule drugs has achieved remarkable c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4406A61K31/56A61P35/00
CPCA61K31/4406A61K31/56A61P35/00A61K2300/00
Inventor 郭守山郭守河
Owner 南京盖斯夫医药科技有限公司
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