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Application of fuziline in preparation of medicine for preventing and treating shock

A technology of Fuziling and medicine, applied in the field of biomedicine

Active Publication Date: 2013-05-29
YAAN THREE NINE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the anti-arrhythmia, anti-heart failure and analgesic activities and uses of aconite have been seen at home and abroad, there is no report on the use of its natural extract Fuziling in ischemic shock.

Method used

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  • Application of fuziline in preparation of medicine for preventing and treating shock
  • Application of fuziline in preparation of medicine for preventing and treating shock
  • Application of fuziline in preparation of medicine for preventing and treating shock

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0129] b. Pass the extract of the total alkaloid part through a neutral alumina column, elute with ethyl acetate, separate the crystalline samples, and combine the viscous samples together to obtain the total extract;

[0130] c. Put the total extract through alkalized silica gel column, elute with petroleum ether-ethyl acetate (1:1) and pure ethyl acetate, collect the ethyl acetate eluate, and carry out recrystallization to obtain Fuziling (2088mg ).

[0131] Example 2

Embodiment 2

[0133] b. Pass the extract of the total alkaloid part through a neutral alumina column, elute with ethyl acetate, separate the crystalline samples, and combine the viscous samples together to obtain the total extract;

[0134] c. Pass the total extract through an alkalized silica gel column, elute with petroleum ether-ethyl acetate (1:1), pure ethyl acetate, collect the ethyl acetate eluate, and carry out recrystallization to obtain Fuziling (2406mg ).

[0135] Example 3

Embodiment 3

[0137] b. Pass the extract of the total alkaloid part through a neutral alumina column, elute with ethyl acetate, separate the crystalline samples, and combine the viscous samples together to obtain the total extract;

[0138] c. Pass the total extract through an alkalized silica gel column, elute with petroleum ether-ethyl acetate (1:1), pure ethyl acetate, collect the ethyl acetate eluate, and carry out recrystallization to obtain Fuziling (1220mg ).

[0139] Example 4

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Abstract

The invention relates to fuziline and a preparation method and an application of medicinal acid addition salt thereof. The fuziline has the structure of a formula (I) and can be applied to preparing the medicine for preventing and treating shock.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the application of Fuziling and its pharmaceutically acceptable acid addition salts in the preparation of drugs for preventing and treating shock. Background technique [0002] Shock is an acute blood circulation disorder characterized by a sharp decrease in tissue perfusion after the body is subjected to strong harmful factors. Causes of shock include: blood and fluid loss, burns, trauma, infection, allergies, acute heart failure, and intense nerve irritation. A large amount of blood loss can cause hemorrhagic shock, which is common in acute hemorrhage such as traumatic hemorrhage, upper gastrointestinal bleeding, ruptured ectopic pregnancy, and postpartum hemorrhage. The occurrence of shock depends on the speed and amount of blood loss. When the blood loss is less than 10% of the whole blood within 15 minutes, the body can generally maintain stable blood pressure and tis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/439C07D221/22A61P7/08
Inventor 潘红炬刘静涵杨春华朱雅宁郝莉李运曼张思佳吴建国刘敏卓祝勇军刘芳胡敏卫天喜
Owner YAAN THREE NINE PHARMA
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