Medicinal composition containing enalapril or genazepril and sotalol
A technology of enalapril and a composition, applied in the field of pharmaceutical compositions, can solve the problems of declining sales, limited antihypertensive efficacy, poor compliance of elderly patients, etc., and achieves enhanced antihypertensive effect and good patient compliance. , the effect of reducing medical costs
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Embodiment 1
[0050] Embodiment 1. preparation contains the compound enalapril sotalol sheet of 10mg enalapril and 20mg sotalol
[0051]
[0052] Preparation process: Take the prescribed amount of enalapril maleate and sotalol hydrochloride through a 100-mesh sieve and then mix them uniformly by the method of equal increments; other excipients are respectively passed through a 100-mesh sieve and dried at 75°C for 2 hours: according to the prescription A certain amount of starch, microcrystalline cellulose, and CMS·Na are mixed evenly, and then mixed with the mixed raw materials in equal increments; adding an appropriate amount of binder to make soft materials, granulating with a 24-mesh sieve, and granulating with a 20-mesh sieve. Dry at 40-45°C; add appropriate amount of magnesium stearate to the dry granules, mix well, measure the content, and press into tablets to obtain the product.
Embodiment 2
[0053] Example 2. Preparation of compound enalapril sotalol tablets containing 10mg enalapril and 40mg sotalol
[0054]
[0055] The preparation method is the same as implementation 1.
Embodiment 3
[0056] Example 3. Preparation of Compound Enalapril Sotalol Tablets Containing 10mg Enalapril and 80mg Sotalol
[0057]
[0058] Preparation method: crush the original and auxiliary materials through a 120-mesh sieve, weigh the prescription amount of enalapril maleate, sotalol hydrochloride, microcrystalline cellulose, starch and sodium carboxymethyl starch, crush and sieve, mix evenly, Use an appropriate amount of 10% starch slurry to make a soft material, granulate, dry at 40°C to 60°C until the water content is about 3%, take it out, granulate, mix the granules with an appropriate amount of talcum powder, and press into 1000 tablets are available.
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Abstract
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