The invention discloses an antihypertensive drug composition, a preparation method of the antihypertensive drug composition and an antihypertensive device using the antihypertensive drug composition. The antihypertensive drug composition comprises, by weight, raw materials of 15-25 parts of virgin soil, 15-25 parts of monkshood, 25-35 parts of fructus evodiae and 7-13 parts of live leech. The preparation method comprises smashing the virgin soil, the monkshood and the fructus evodiae to obtain dry powder; soaking the live leech by using alcohol, grinding the alcohol and the live leech to form slurry, adding the dry powder, soaking for more than 15 days, dying in a vacuum mode to obtain the antihypertensive drug composition. The antihypertensive device comprises an electric pulse generator, an antihypertensive paste and a lead connected between the output end of the electric pulse generator and the antihypertensive paste, and the antihypertensive paste comprises adhesive plaster and a drug bag which is arranged on a pasting face of the adhesive plaster and filled with the antihypertensive drug composition. The antihypertensive drug composition is simple in prescription and wide in raw material resource, and is an effective external use antihypertensive drug. A preparation process is simple and easy to control, and no complex equipment is needed. The antihypertensive device is simple in structure and can effectively reduce blood pressure through acupoint pressing, drug permeation and electric pulse stimulation.