Process for extracting ursolic acid from fructus ligustri lucidi leaf

A technology of ursolic acid and privet leaf, applied in the directions of steroids, organic chemistry, etc., can solve the problems of large amount of "three wastes", high cost of ursolic acid, environmental pollution, etc., and achieves easy treatment and low cost. , the effect of the simple method

Inactive Publication Date: 2003-11-05
WUHAN UNIV
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  • Abstract
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Problems solved by technology

[0005] Although ursolic acid can be synthesized by chemical methods, this kind of method not only has a large amount of "three wastes" and is difficult to deal with, it is easy to pollute the environment, and the cost of obtained ursolic acid is relatively high

Method used

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Embodiment Construction

[0011] The pulverized privet leaves are extracted 2-3 times with 5-6 times (W / V) ethanol back flow to obtain a liquid extract, and the ethanol is recovered. The above-mentioned extract is fully washed with water and dried at 80°C to obtain dry Extract, after dissolving dry extract in ethanol, decolorize with activated carbon, add water to precipitate a large amount of precipitate after recovering ethanol, adjust the pH value to 2-2.5, separate and collect the precipitate, wash with water until neutral, and dry in vacuum. Obtain the crude extract whose main component is ursolic acid.

[0012] Dissolve the above-mentioned crude extract in hot ethanol, add silica gel, mix well, evaporate the ethanol under infrared light, and put it on the column by dry method, that is, evenly load 200 mesh silica gel G (Qingdao Haiyang Produced by a chemical factory, used for thin-layer chromatography), pumped under reduced pressure, dissolved 3 grams of the sample in an appropriate amount of anh...

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Abstract

The invention relates to a method for extracting ursolic acid from privet leaves. The pulverized privet leaves are refluxed with ethanol to obtain a liquid extract, and the ethanol is recovered. The above extracts are fully washed with water and then dried to obtain dry Extract, dry extract is decolorized after dissolving with ethanol, after recovering ethanol, add water to precipitate a large number of precipitates, adjust the pH value to 2-2.5, separate and collect the precipitate, wash with water until neutral, and dry in vacuum to obtain the main components Crude extract of ursolic acid. The present invention adopts the above-mentioned method, and takes the cheap and easy-to-obtain Jurchen leaves as raw materials and extracts them under reflux with ethanol. The amount of "three wastes" is small and easy to handle, ethanol can be recycled and reused, and the residue left after extraction can be used as fertilizer. Therefore, the present invention basically does not pollute the environment, and the cost of the obtained ursolic acid is relatively low. In addition, the method of the present invention is simple and fast.

Description

1. Technical field [0001] The invention relates to a method for extracting ursolic acid from privet leaves. 2. Background technology [0002] Ligustrum is a plant of the genus Ligustrum of the Oleaceae family. The scientific name is Ligustrum Lucidum Ait. It is a large evergreen shrub or small tree in all seasons. There are about 50 species in the world, and there are 38 species in my country. They are widely distributed in East China, South China, Southwest China and Central China is rich in plant resources and widely distributed. [0003] With the deepening of pharmacological research, it is found that privet plants have various physiological activities, but the research on the chemical constituents of privet plants is not enough. For a long time, the parts of the privet plant we have studied have not been fully utilized, basically not used as medicine, and there is a lot of waste. [0004] Ursolic acid is a triterpenoid compound with the molecular formula C 30 h 48 o ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J63/00
Inventor 樊明文边专王茜谭文界
Owner WUHAN UNIV
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