Application of dendrobium crepidatum pyridine base A in preparation of anti-pulmonary fibrosis medicine

A technology for pulmonary fibrosis and ellipidine, which is used in the application field of ellipticine A in the preparation of anti-pulmonary fibrosis drugs

Active Publication Date: 2021-05-18
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no literature report that elathidine A and other analogues have pharmacological efficacy in the treatment of pulmonary fibrosis and their application in drugs for the treatment of pulmonary fibrosis

Method used

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  • Application of dendrobium crepidatum pyridine base A in preparation of anti-pulmonary fibrosis medicine
  • Application of dendrobium crepidatum pyridine base A in preparation of anti-pulmonary fibrosis medicine
  • Application of dendrobium crepidatum pyridine base A in preparation of anti-pulmonary fibrosis medicine

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Experimental program
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Embodiment Construction

[0018] 1. Preparation and structure confirmation of rosidine A

[0019] Dendrobium rosea is the fresh or dried stem of Dendrobium crepidatum Lindl. ex Paxt., which was purchased from Bozhou, Anhui. Reagents such as ethanol and petroleum ether were of analytical grade.

[0020] Dried stems of Dendrobium nodulum were reflux extracted with 80% ethanol 15 times the amount of the crude drug for 3 times, each time for 2.5 hours, filtered, combined extracts, and decompressed to remove ethanol to obtain the total extract; dissolve the total extract in 5 times Extract crude drug amount of water with petroleum ether (60-90°C), ethyl acetate and n-butanol in sequence, and the ethyl acetate extract is subjected to silica gel column chromatography (petroleum ether / ethyl acetate, 98:2→1:1 ) separation, and then continue to be further separated by silica gel column chromatography (CHCl3 / →5:1), and finally purified on the RP-18 silica gel column to obtain the compound rosidine A.

[0021] S...

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Abstract

The invention relates to application of dendrobium crepidatum pyridine base A as a medicine for treating pulmonary fibrosis. The compound dendrobium crepidatum pyridine base A is obtained from a traditional Chinese medicinal material dendrobium crepidatum, and the structure is determined through NMR and other spectrum data; and in-vivo and in-vitro pharmacological experiment results prove that the dendrobium crepidatum pyridine base A can remarkably inhibit the proliferation of primary fibroblasts induced by TGF-[beta]1, and can improve the fibrosis degree of lung tissues in a bleomycin-induced mouse pulmonary fibrosis model so as to take the pharmacological effect of improving the pulmonary fibrosis degree.

Description

technical field [0001] The present invention relates to the use of compound rosidine A as a medicine for treating pulmonary fibrosis. Background technique [0002] Pulmonary fibrosis is a progressive disease characterized by fibrosis and lung parenchymal remodeling. Pulmonary fibroblasts hyperproliferate, transdifferentiate into myofibroblasts, secrete a large amount of collagen and deposit matrix. There is no effective treatment. However, pulmonary fibrosis and pneumonia are not the same disease, and the pathogenesis of pneumonia has not been fully understood. It is generally believed to be related to bronchial obstruction and protease-antiprotease imbalance. Smoking, infection, and air pollution can cause bronchiolar inflammation, narrowing or obstruction of the lumen. When inhaling, the lumen of the bronchioles expands, and air enters the alveoli; when exhaling, the lumen of the bronchioles shrinks, air is trapped, and the intraalveolar pressure continues to increase, ...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K31/437A61P11/00
CPCA61K31/437A61P11/00Y02A50/30
Inventor张朝凤任国庆李任时
OwnerCHINA PHARM UNIV