Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of new interaction of plasma metabolism in skin microflora of psoriasis patient

A technology of patients and microorganisms, applied in the field of dermatology, can solve the problems of unclear skin microbiota psoriasis patients' potential function, unclear skin microbiota organizational structure, etc.

Active Publication Date: 2021-05-18
GENERAL HOSPITAL OF NINGXIA MEDICAL UNIV
View PDF11 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, much remains unknown about the organization of the skin microbiota and its potential function in regulating overall metabolism in psoriasis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0029] Application of plasma metabolism to novel interactions of skin microflora in psoriasis patients.

[0030] Through the application steps described in the summary of the present invention, the following results are produced:

[0031] (1) Changes in the skin microflora composition of psoriasis patients.

[0032] We recruited 32 patients with severe plaque psoriasis (PASI >12) and 29 healthy controls to identify psoriasis-associated flora. After quality control, the DNA sample size of only 26 patients and 10 controls was sufficient for 16S sequencing. Overall, we obtained a total of 83998 valid labels and 7887 OTUs with a 97% similarity. After classification according to the Silva132 database, 7606 OTUs were annotated at different phylogenetic levels. Current sequencing and samples are sufficient for taxon identification based on species accumulation curves. However, there was no significant difference in the number of skin types between controls and psoriasis patients....

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses application of new interaction of plasma metabolism in skin microflora of a psoriasis patient. The application comprises collection of patient group information and healthy control group information, sample collection, microbiome DNA extraction and 16S sequencing, 16S sequencing data analysis, LC-MS metabonomics data collection, GC-MS data collection, and metabonomics data analysis and statistical analysis by utilizing LC-MS and GC-MS. The skin microbiome 16S sequence and the plasma metabonomics data are integrated, the change of the global metabolism steady state of the psoriasis patient and the relationship between the global metabolism steady state and the skin microflora are disclosed, and the application of the new interaction of the plasma metabolism in the key skin microflora in the psoriasis pathogenesis is disclosed. The data provided by the invention provides a potential mechanism for the skin microbiota of the psoriasis patient to regulate blood metabolism, which is helpful for further understanding the pathological mechanism of psoriasis.

Description

technical field [0001] The invention belongs to the technical field of dermatology, and particularly relates to the application of a new interaction of blood plasma metabolism in the skin microbiota of psoriasis patients. Background technique [0002] Psoriasis is one of the most common skin diseases worldwide, affecting approximately 2% of the population (Boehncke and 2015). Symptoms of psoriasis are often uncomfortable and affect other organs more than just the skin. At present, the molecular mechanism of psoriasis is still unclear, and it is difficult to find new therapeutic drugs. In this case, most patients have to suffer from the disease for life (Dubertret et al., 2006; Nestle et al., 2009). [0003] The etiology of psoriasis remains largely unknown, but has been reported to be multifaceted, including environmental, genetic, and immune factors (Nestle et al., 2009). It has been reported that tumor onset, progression, and even recurrence after clinical treatment a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G16B20/20G16H50/70G06K9/62
CPCG16B20/20G16H50/70G06F18/2135Y02A90/10
Inventor 施惠娟陈冬梅
Owner GENERAL HOSPITAL OF NINGXIA MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com