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Polysaccharide freeze-dried powder with anti-depression effect as well as preparation method and application thereof

A polysaccharide freeze-dried powder, antidepressant technology, applied in the field of medicine, can solve problems such as long treatment cycle, achieve strong antidepressant effect, increase activity score, increase sugar water preference rate

Active Publication Date: 2021-05-28
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Patients with depression often need to take medicine for a long time, and the treatment cycle is longer

Method used

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  • Polysaccharide freeze-dried powder with anti-depression effect as well as preparation method and application thereof
  • Polysaccharide freeze-dried powder with anti-depression effect as well as preparation method and application thereof
  • Polysaccharide freeze-dried powder with anti-depression effect as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Take dried Yinbupleurum decoction pieces, add distilled water at a material-to-liquid ratio of 1:20 (w / v), boil water for extraction for 1 hour, collect the extract and filter residue by filtration; repeat the extraction of the filter residue twice, each time for 1 hour. The combined extracts were concentrated with a vacuum pump connected to a rotary evaporator at 65 °C under reduced pressure. The concentrated solution was precipitated with 95% ethanol to a final alcohol concentration of 80%, left overnight at 4 °C, and centrifuged at 4000 rpm for 10 min to collect the precipitate. The precipitate was redissolved with distilled water, the protein was removed by sevag method, the liquid in the aqueous layer was collected, concentrated and then freeze-dried to obtain the freeze-dried powder of silver Bupleurum polysaccharide.

[0043] Adopt phenol-sulfuric acid method to measure the polysaccharide content of polysaccharide freeze-dried powder of silver Bupleurum polysaccha...

Embodiment 2

[0045] Take dried Yinchaihu decoction pieces, add distilled water at a material-to-liquid ratio of 1:25 (w / v), boil water for extraction for 1.5 hours, collect the extract and filter residue by filtration; repeat the extraction once for 1.5 hours each time. The combined extracts were concentrated with a vacuum pump connected to a rotary evaporator at 65 °C under reduced pressure. The concentrated solution was precipitated with 95% ethanol to a final alcohol concentration of 80%, left overnight at 4 °C, and centrifuged at 4000 rpm for 10 min to collect the precipitate. The precipitate was redissolved with distilled water, the protein was removed by sevag method, the liquid in the aqueous layer was collected, concentrated and then freeze-dried to obtain the freeze-dried powder of silver Bupleurum polysaccharide.

Embodiment 3

[0047] Take dried Yinchaihu decoction pieces, add distilled water at a material-to-liquid ratio of 1:20 (w / v), boil water for extraction for 1 hour, collect the extract and filter residue by filtration; repeat the extraction of the filter residue twice, each time for 0.5 h. The combined extracts were concentrated with a vacuum pump connected to a rotary evaporator at 65 °C under reduced pressure. The concentrated solution was precipitated with 95% ethanol to a final alcohol concentration of 80%, left overnight at 4 °C, and centrifuged at 4000 rpm for 10 min to collect the precipitate. The precipitate was redissolved with distilled water, the protein was removed by sevag method, the liquid in the aqueous layer was collected, concentrated and then freeze-dried to obtain the freeze-dried powder of silver Bupleurum polysaccharide.

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PUM

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Abstract

The invention discloses polysaccharide freeze-dried powder with an anti-depression effect as well as a preparation method and application of the polysaccharide freeze-dried powder, and belongs to the technical field of medicines. The polysaccharide freeze-dried powder is prepared by taking starwort root as a raw material through water extraction and alcohol precipitation, precipitate collection, redissolution for deproteinization, concentration and freeze-drying. The raw materials are natural and safe, no serious side effect is caused, the anti-depression effect can be effectively achieved, and the polysaccharide freeze-dried powder can be used for preparing the medicine for preventing and treating depression.

Description

technical field [0001] The invention relates to the technical field of medicine, and more specifically relates to a freeze-dried polysaccharide powder with antidepressant effect and its preparation method and application. Background technique [0002] Depression is one of the most common mental illnesses, clinically manifested as depression, low self-esteem, anhedonia, despair, etc., while some patients are accompanied by anxiety, and severe patients may have suicide attempts or behaviors, etc. The disease is characterized by recurrent attacks , often accompanied by serious psychological and physical disorders, which are extremely harmful to human health. In recent years, with the rapid development of the economy and the increasing pressure of social competition, the incidence of depression has increased rapidly. [0003] Patients with depression often need to take medicine for a long time, and the treatment cycle is longer. At present, the antidepressants commonly used in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K9/19A61K36/36A61P25/24C08B37/00
CPCA61K31/715A61K36/36A61K9/19A61P25/24C08B37/0003A61K2236/331A61K2236/53
Inventor 董琳陈淑娟黄换玲权洪峰付雪艳周希蓉秦宇崔宏昇
Owner NINGXIA MEDICAL UNIV
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