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Local fat-reducing composition and application thereof

A composition and local technology, applied in the field of treatment of thyroid-associated ophthalmopathy and local fat reduction. In the field of local fat-reducing composition, it can solve problems such as fat accumulation in unapplicable thyroid-associated ophthalmopathy.

Inactive Publication Date: 2021-07-23
深圳市百吉因生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method is not suitable for the treatment of fat accumulation in thyroid-related eye disease because the technique hydrolyzes fat throughout the body and is not controlled

Method used

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  • Local fat-reducing composition and application thereof
  • Local fat-reducing composition and application thereof
  • Local fat-reducing composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Add the raw materials for preparing the solvent into the water phase pot of the homogeneous emulsifier according to the following formula and stir at 400 rpm: 0.93 grams of water, 0.05 grams of glycerin, 0.003 grams of tranexamic acid, 0.002 grams of glutathione, and 0.001 grams of butanediol , 0.001 gram of taurine, 0.001 gram of potassium methoxysalicylate, 0.001 gram of caprylic acid ester, 0.002 gram of caprylyl hydroxamic acid, 0.001 gram of p-hydroxyacetophenone, 0.001 gram of carnosine, 0.002 gram of Alcaligenes multi Sugar, 0.003 g of dipotassium glycyrrhizinate and 0.002 g of phenoxyethanol, after stirring for 20 minutes, add transdermal decapeptide-4 and AdPLA-siRNA1, the ratio of the three is 1g vehicle: 0.1mg transdermal decapeptide-4: 10ngAdPLA -siRNA1, continue to stir for 10 minutes to obtain the local fat-reducing product of Example 1.

Embodiment 2

[0048] It is basically the same as Example 1, except that the ratio of the three is 1g vehicle: 0.1mg transdermal decapeptide-4: 25ng AdPLA-siRNA1, and the local fat-reducing product of Example 2 is obtained.

Embodiment 3

[0050] It is basically the same as Example 1, except that the ratio of the three is 1g vehicle: 0.1mg transdermal decapeptide-4: 50ng AdPLA-siRNA1, and the local fat-reducing product of Example 3 is obtained.

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Abstract

The invention discloses a local fat-reducing composition. The composition comprises a solvent, transdermal peptide and small interfering nucleic acid aiming at an AdPLA gene, wherein the solvent is prepared from the following raw materials: water, glycerol, tranexamic acid, glutathione, butanediol, taurine, potassium methoxysalicylate, glycerol caprylate, capryloyl hydroximic acid, p-hydroxyacetophenone, carnosine, alcaligenes polysaccharide, dipotassium glycyrrhizinate and phenoxyethanol; and a ratio of the solvent to the transdermal peptide to the small interfering nucleic acid aiming at the AdPLA gene is 1 g of the solvent to 0.1-0.5 mg of the transdermal peptide to 10-100 ng of the small interfering nucleic acid aiming at the AdPLA gene. The invention also provides application of the fat-reducing composition in preparation of drugs for treating thyroid eye diseases and local fat-reducing products.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a local fat-reducing composition and its application in the fields of treating thyroid-associated ophthalmopathy and local fat-reducing. Background technique [0002] Thyroid-associated ophthalmopathy is the most common autoimmune ophthalmopathy in adults closely associated with thyroid disease, manifesting as exophthalmos, delayed eyelid retraction, periorbital swelling, restrictive extraocular muscle lesions, exposure keratitis, and compressive optic neuropathy Wait. Exophthalmos is caused by increased orbital fat, orbital fatty connective tissue, inflammatory cell infiltration and polysaccharide deposition in extraocular muscles. About 52% of patients had exophthalmos due to increased orbital fat. The increase in orbital fat is caused by the increase in the number of adipocytes and the increase in the volume of adipocytes. Both increased lipogenesis and decreased hydrolys...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/60A61Q19/06A61P43/00A61P27/02
CPCA61K8/64A61K8/606A61Q19/06A61P43/00A61P27/02
Inventor 汤涛邓艳宋艺
Owner 深圳市百吉因生物科技有限公司
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