Application of cinnamic acid in preparation of drugs for treating myelosuppression caused by cyclophosphamide
A technology of myelosuppression and cyclophosphamide, which is applied in the application field of medicine, to achieve the effect of alleviating the decrease and increase of peripheral blood images
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[0015] (1) Drugs and drug doses
[0016] Cinnamic acid: 6mg / kg, 12mg / kg, 24mg / kg, its purity detected by liquid chromatography is 98.12%. Positive drug: Cyclophosphamide 120mg / kg, purchased from Qilu Pharmaceutical Co., Ltd. (batch number: 20150203).
[0017] (2) Modeling and methods
[0018] Take 50 SPF mice, half male and half male, weighing 20±2g, and divide them into 5 groups, 10 mice in each group.
[0019] Among them, ① the blank group was administered intragastrically with the same volume of normal saline (0.2mL / 10g);
[0020] ②For the model group, the same volume of normal saline (0.2mL / 10g) was intragastrically administered;
[0021] ③High dose group of cinnamic acid;
[0022] ④ The middle dose group of cinnamic acid;
[0023] ⑤ Low-dose cinnamic acid group.
[0024] Intragastric administration, administration once a day, continuous administration for 10d. From the 6th day after the first administration, except the blank group, the mice in each group were intra...
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