A kind of nattokinase transdermal absorption agent for external use and preparation method thereof

Abstract

The invention discloses a nattokinase transdermal absorbent for external use and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. The nattokinase transdermal absorbent for external use of the present invention is to add the nattokinase molecular microcapsules into the blank matrix by the method of equal addition, make it evenly dispersed, then add humectant, emulsifier, penetration enhancer, stir Evenly, add a pH regulator to adjust the pH value to 6‑7. The nattokinase transdermal absorbent for external use provided by the invention can avoid the low bioavailability and liver first-pass effect caused by oral administration, has the characteristics of good absorption and strong stability, and overcomes the difficulty of nattokinase due to its large molecular weight. The disadvantage of transdermal absorption has realized the goal of external application of nattokinase in treating cardiovascular and cerebrovascular diseases.

Description

A kind of nattokinase external use transdermal absorber and preparation method thereof technical field The invention belongs to the technical field of medicine preparation, be specifically related to a kind of nattokinase external transdermal absorption agent and preparation thereof method. Background technique The data shows that the overall prevalence of dyslipidemia in Chinese adults is as high as 40.4%, and lipid-lowering drug packs are commonly used in clinical practice at present. Including statins, vitamin B3, fibrates, bile acid chelators, polyene fatty acids, etc. Among them, statins are the most commonly used Its lipid-lowering effect is good, but long-term high-dose use will lead to dose-dependence, headache, gastrointestinal symptoms, etc. and muscle adverse reactions (myositis, rhabdomyolysis) and other side effects, and these lipid-lowering drugs are mostly administered orally or intravenously Intravenous administration and application methods have no...

AI Technical Summary

Problems solved by technology

[0005] The invention provides an external transdermal absorbent for nattokinase, which has good absorbability and strong stability, solves the problem of poor transdermal properties of nattokinase, and overcomes the low and stable bioavailability of nattokinase when it is taken as an oral preparation sex problem

Images