Traditional Chinese medicine composition containing guiding drug achyranthes bidentata for treating Yin deficiency and heat excess type non-alcoholic fatty liver disease and preparation method and application thereof

A non-alcoholic, yin-deficiency and heat-abundant technology, applied in the field of medicine, can solve the problem of no literature reports on the specific induction of fatty liver transporters in the synergistic effect

Active Publication Date: 2021-08-20
THE CHINESE TRADITIONAL HERB MEDICINE RES INST HENAN PROV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the synergistic effect of Achyranthes bidentata on the treatment of non-alcoholic fatty liver by related drugs ...

Method used

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  • Traditional Chinese medicine composition containing guiding drug achyranthes bidentata for treating Yin deficiency and heat excess type non-alcoholic fatty liver disease and preparation method and application thereof
  • Traditional Chinese medicine composition containing guiding drug achyranthes bidentata for treating Yin deficiency and heat excess type non-alcoholic fatty liver disease and preparation method and application thereof
  • Traditional Chinese medicine composition containing guiding drug achyranthes bidentata for treating Yin deficiency and heat excess type non-alcoholic fatty liver disease and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A traditional Chinese medicine composition containing achyranthes bidentata for treating non-alcoholic fatty liver caused by yin deficiency and excessive heat, comprising the following raw materials in parts by weight: 9 parts of Achyranthes bidentata, 20 parts of Radix Ophiopogon japonicus, 15 parts of Anemarrhena anemarrhenae, duck plantar 30 parts of grass, 20 parts of Dijin grass, 9 parts of schisandra, 18 parts of Tianjihuang, 14 parts of Daidaihua, 9 parts of lotus leaf, 9 parts of kapok, and 6 parts of Dabupi.

[0031] Its preparation method is (water decoction): mix the raw materials, add 5 times the weight of water, soak for 2 hours, decoct for 30 minutes, filter, add 8 times the weight of water in the filter residue, decoct for 60 minutes, filter , combined two filtrates, that is.

Embodiment 2

[0033] A traditional Chinese medicine composition containing achyranthes bidentata for treating non-alcoholic fatty liver caused by yin deficiency and excessive heat, comprising the following raw materials in parts by weight: 12 parts of Achyranthes bidentata, 24 parts of Radix Ophiopogon japonicus, 20 parts of Anemarrhena anemarrhenae, duck plantar 36 parts of grass, 24 parts of Dijin grass, 9 parts of Schisandra chinensis, 21 parts of Tianjihuang, 18 parts of Daidaihua, 12 parts of lotus leaf, 9 parts of kapok, and 9 parts of Dabupi.

[0034] Its preparation method is (water decoction): mix the raw materials, add 8 times the weight of water, soak for 2 hours, decoct for 20 minutes, filter, add 8 times the weight of water in the filter residue, decoct for 90 minutes, filter , combined two filtrates, that is.

Embodiment 3

[0036]A traditional Chinese medicine composition containing achyranthes bidentata for treating non-alcoholic fatty liver caused by yin deficiency and excessive heat, comprising the following raw materials in parts by weight: 9 parts of Achyranthes bidentata, 20 parts of Radix Ophiopogon japonicus, 15 parts of Anemarrhena anemarrhenae, duck plantar 30 parts of grass, 20 parts of Dijin grass, 9 parts of schisandra, 18 parts of Tianjihuang, 14 parts of Daidaihua, 9 parts of lotus leaf, 9 parts of kapok, and 6 parts of Dabupi.

[0037] Its preparation method comprises the following steps (granules):

[0038] 1) Take Schisandra chinensis, Tianjihuang, Daidaihua, Kapok, and lotus leaves, mix and grind them into coarse powder, add 8 times the weight of 70% (v / v) ethanol solution, soak for 2 hours, and reflux extract 3 times , 1.5 hours each time, combine the extracts, reclaim ethanol, concentrate the extracts, dry in vacuum to obtain the extracts, pulverize the extracts and pass thro...

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Abstract

The invention discloses a traditional Chinese medicine composition containing a guiding drug achyranthes bidentata for treating a Yin deficiency and heat excess type non-alcoholic fatty liver disease and a preparation method and application thereof. The composition is prepared from, by weight, 6-18 parts of achyranthes bidentata, 12-30 parts of radix ophiopogonis, 6-25 parts of rhizoma anemarrhenae, 15-45 parts of dayflower, 9-27 parts of humifuse euphorbia herb, 3-12 parts of schisandra chinensis, 12-24 parts of hypericum japonicum, 10-20 parts of seville orange flowers, 6-15 parts of lotus leaves, 6-12 parts of common bombax flowers and 3-12 parts of pericarpium arecae. Research shows that the composition prepared from radix ophiopogonis, rhizoma anemarrhenae, dayflower, humifuse euphorbia herb, schisandra chinensis, hypericum japonicum, seville orange flowers, lotus leaves, common bombax flowers and pericarpium arecae has a certain treatment effect on the Yin deficiency and heat excess type non-alcoholic fatty liver disease, when the composition is used in cooperation with achyranthes bidentata, achyranthes bidentata can increase the distribution concentration of other medicine effective ingredients in liver tissue by up-regulating expression of Oatp1b2, and a good synergistic effect is generated.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition containing achyranthes bidentata for treating non-alcoholic fatty liver of yin deficiency and heat excess type, a preparation method and application thereof, and belongs to the field of medicine. Background technique [0002] In recent years, with the improvement of people's living standards, the incidence of non-alcoholic fatty liver has been increasing year by year. The prevalence rate of the general population is about 20% to 33%, and the obesity population is about 57% to 74%. 70% to 80%, the prevalence of diabetes combined with obesity is almost 100%. Non-alcoholic fatty liver (nonalcoholic fatty liverdisease, NAFLD) is a disease without a history of excessive drinking, which is caused by a variety of reasons leading to hepatic lipodystrophy, lipid homeostasis imbalance, resulting in excessive accumulation of lipids in liver cells, and diffuse liver disease. Clinical syndrome of ...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K36/21A61P1/16
CPCA61K36/21A61K36/8968A61K36/8964A61K36/88A61K36/47A61K36/79A61K36/57A61K36/185A61K36/752A61K36/62A61K36/889A61P1/16A61K2236/333A61K2236/39A61K2236/331A61K2236/51A61K2300/00
Inventor 梁瑞峰葛文静宋献美张艳燕李更生崔伟锋张社峰
Owner THE CHINESE TRADITIONAL HERB MEDICINE RES INST HENAN PROV
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