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A traditional Chinese medicine composition containing achyranthes bidentata for treating non-alcoholic fatty liver of yin deficiency and excessive heat, and its preparation method and application

A non-alcoholic, yin-deficiency and heat-rich technology, applied in the field of medicine, can solve the problem of synergistic effect of fatty liver transporter specific induction without literature reports and so on.

Active Publication Date: 2022-04-26
THE CHINESE TRADITIONAL HERB MEDICINE RES INST HENAN PROV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the synergistic effect of Achyranthes bidentata on the treatment of non-alcoholic fatty liver by related drugs and the specific induction of Achyranthes bidentata on fatty liver transporters are not reported in the literature at present.

Method used

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  • A traditional Chinese medicine composition containing achyranthes bidentata for treating non-alcoholic fatty liver of yin deficiency and excessive heat, and its preparation method and application
  • A traditional Chinese medicine composition containing achyranthes bidentata for treating non-alcoholic fatty liver of yin deficiency and excessive heat, and its preparation method and application
  • A traditional Chinese medicine composition containing achyranthes bidentata for treating non-alcoholic fatty liver of yin deficiency and excessive heat, and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A traditional Chinese medicine composition containing achyranthes bidentata for treating non-alcoholic fatty liver caused by yin deficiency and excessive heat, comprising the following raw materials in parts by weight: 9 parts of Achyranthes bidentata, 20 parts of Radix Ophiopogon japonicus, 15 parts of Anemarrhena anemarrhenae, duck plantar 30 parts of grass, 20 parts of Dijin grass, 9 parts of schisandra, 18 parts of Tianjihuang, 14 parts of Daidaihua, 9 parts of lotus leaf, 9 parts of kapok, and 6 parts of Dabupi.

[0031] Its preparation method is (water decoction): mix the raw materials, add 5 times the weight of water, soak for 2 hours, decoct for 30 minutes, filter, add 8 times the weight of water in the filter residue, decoct for 60 minutes, filter , combined two filtrates, that is.

Embodiment 2

[0033] A traditional Chinese medicine composition containing achyranthes bidentata for treating non-alcoholic fatty liver caused by yin deficiency and excessive heat, comprising the following raw materials in parts by weight: 12 parts of Achyranthes bidentata, 24 parts of Radix Ophiopogon japonicus, 20 parts of Anemarrhena anemarrhenae, duck plantar 36 parts of grass, 24 parts of Dijin grass, 9 parts of Schisandra chinensis, 21 parts of Tianjihuang, 18 parts of Daidaihua, 12 parts of lotus leaf, 9 parts of kapok, and 9 parts of Dabupi.

[0034] Its preparation method is (water decoction): mix the raw materials, add 8 times the weight of water, soak for 2 hours, decoct for 20 minutes, filter, add 8 times the weight of water in the filter residue, decoct for 90 minutes, filter , combined two filtrates, that is.

Embodiment 3

[0036]A traditional Chinese medicine composition containing achyranthes bidentata for treating non-alcoholic fatty liver caused by yin deficiency and excessive heat, comprising the following raw materials in parts by weight: 9 parts of Achyranthes bidentata, 20 parts of Radix Ophiopogon japonicus, 15 parts of Anemarrhena anemarrhenae, duck plantar 30 parts of grass, 20 parts of Dijin grass, 9 parts of schisandra, 18 parts of Tianjihuang, 14 parts of Daidaihua, 9 parts of lotus leaf, 9 parts of kapok, and 6 parts of Dabupi.

[0037] Its preparation method comprises the following steps (granules):

[0038] 1) Take Schisandra chinensis, Tianjihuang, Daidaihua, Kapok, and lotus leaves, mix and grind them into coarse powder, add 8 times the weight of 70% (v / v) ethanol solution, soak for 2 hours, and reflux extract 3 times , 1.5 hours each time, combine the extracts, reclaim ethanol, concentrate the extracts, dry in vacuum to obtain the extracts, pulverize the extracts and pass thro...

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Abstract

The invention discloses a traditional Chinese medicine composition containing Achyranthes bidentata for treating non-alcoholic fatty liver of yin deficiency and excessive heat type, and its preparation method and application. The composition includes the following raw materials in parts by weight: Achyranthes bidentata 6~ 18 parts, 12-30 parts of Ophiopogon japonicus, 6-25 parts of Anemarrhena, 15-45 parts of Commelina, 9-27 parts of Dijincao, 3-12 parts of Schisandra, 12-24 parts of Tianjihuang, Daidaihua 10-20 parts, 6-15 parts of lotus leaf, 6-12 parts of kapok, 3-12 parts of Dabupi. The inventors of the present invention have found through research that the composition composed of Ophiopogon japonicus, Anemarrhena, Commelina, Dijincao, Schisandra, Tianjihuang, Daidaihua, lotus leaf, kapok, and Dabupi is effective against yin deficiency and heat. Sheng non-alcoholic fatty liver has a certain therapeutic effect. When used in combination with Achyranthes bidentata, Achyranthes bidentata can increase the distribution concentration of active ingredients of other drugs in liver tissue by up-regulating the expression of Oatp1b2, resulting in a better synergistic effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition containing achyranthes bidentata for treating non-alcoholic fatty liver of yin deficiency and heat excess type, a preparation method and application thereof, and belongs to the field of medicine. Background technique [0002] In recent years, with the improvement of people's living standards, the incidence of non-alcoholic fatty liver has been increasing year by year. The prevalence rate of the general population is about 20% to 33%, and the obesity population is about 57% to 74%. 70% to 80%, the prevalence of diabetes combined with obesity is almost 100%. Non-alcoholic fatty liver (nonalcoholic fatty liverdisease, NAFLD) is a disease without a history of excessive drinking, which is caused by a variety of reasons leading to hepatic lipodystrophy, lipid homeostasis imbalance, resulting in excessive accumulation of lipids in liver cells, and diffuse liver disease. Clinical syndrome of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61K36/21A61P1/16
CPCA61K36/21A61K36/8968A61K36/8964A61K36/88A61K36/47A61K36/79A61K36/57A61K36/185A61K36/752A61K36/62A61K36/889A61P1/16A61K2236/333A61K2236/39A61K2236/331A61K2236/51A61K2300/00
Inventor 梁瑞峰葛文静宋献美张艳燕李更生崔伟锋张社峰
Owner THE CHINESE TRADITIONAL HERB MEDICINE RES INST HENAN PROV
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