Reagent and application for differentiating ovarian endometriosis/ovarian cancer
A technology for endometriosis and ectopic disease, which is applied in biological tests, instruments, measuring devices, etc., to achieve the effect of improving accuracy, accurate treatment measures, and optimal treatment effects
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Embodiment 1
[0044] Example 1 Screening for protein markers related to EM / OC / FEM
[0045] 1. Experimental materials
[0046] 1. Research sample
[0047] A total of 30 patients with three groups of disease types who were treated in the Obstetrics and Gynecology Department of Peking Union Medical College Hospital from January 2019 to January 2020 were collected and included. The basic information of the patients is shown in Table 1.
[0048] (1) Ovarian endometriosis group (EM group): 10 cases: The included patients did not receive endometriosis-related drug treatment for half a year before operation.
[0049] (2) Ovarian malignant tumor group (OC group): 10 cases: the pathology was consistent with epithelial ovarian cancer.
[0050] (3) Other benign tumors of the ovary (FEM group): 10 cases: Pathologically excluded complicated endometriosis.
[0051] Table 1 Basic information of the patient population screened by protein markers
[0052]
[0053] IQR: interquartile range;
[0054] #...
Embodiment 2
[0157] Example 2 Validation of protein markers
[0158] 1. Experimental materials
[0159] 1. Research sample
[0160] From January 2019 to January 2020, serum samples of 203 inpatients in the Department of Obstetrics and Gynecology of Peking Union Medical College Hospital were collected for protein marker verification, including 88 patients in the EM group, 90 patients in the FEM group, and 25 patients in the OC group. For example, the basic information of all included patients is shown in Table 6.
[0161] Sample inclusion criteria:
[0162] Inclusion criteria: a. Adnexal tumors or pelvic masses found by ultrasound results, suspicious EM or OC or unknown significance; b. Surgical treatment confirmed at Peking Union Medical College Hospital.
[0163] Exclusion criteria: a. Combined with other gynecological benign and malignant tumors; b. Clinically suspected malignant tumors; c. Other systemic malignant tumors or a history of malignant tumors; d. Pregnancy.
[0164] Table...
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