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A DNA hybridization information storage encryption method based on dual probe specific separation

A technology of information storage and encryption method, applied in the fields of informatics, bioinformatics, genomics, etc., can solve the problem that the DNA hybrid storage technology has not yet realized the encryption function, and achieve the effect of high security

Active Publication Date: 2022-07-29
HUNAN UNIV OF SCI & TECH
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Problems solved by technology

[0003] The technical problem to be solved by the present invention: Aiming at the problem that the existing DNA hybridization storage technology has not yet realized the encryption function, an encryption method for storing DNA hybridization information is provided. Encrypt the probes separately, and activate the probes by separating the double probes with a specific endonuclease, realizing a hard encryption method for DNA hybridization storage technology

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  • A DNA hybridization information storage encryption method based on dual probe specific separation
  • A DNA hybridization information storage encryption method based on dual probe specific separation

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Embodiment Construction

[0034] The following will take the writing target information "encryption" (two Chinese characters) as an example to further describe the DNA information storage encryption method of the present invention.

[0035] like figure 2 As shown, the present embodiment DNA information storage parallel addressing and writing method includes:

[0036] 1) The target information, namely "encryption" two Chinese characters are converted into binary codes, 10111100110100111100001111011100 and divided into 8 fields, each field corresponds to a data unit, including 4 binary digits;

[0037] 2) Map the 1 / 0 value on the 4 binary digits of each of the above fields to the presence / absence combination of the 4 DNA coding strands B1, B2, B3, and B4; for example, the first digit (corresponding to B1) has Coding strand, the value of this digit is 1, otherwise it is 0, thus obtaining a list of coding strands that need to be added to all data units on the DNA storage disk; taking the above 8 data uni...

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Abstract

The invention discloses a DNA storage encryption method based on the specific separation of dual probes. The invention includes a set of DNA double probe strands with dual fluorescent groups and restriction endonuclease recognition sites and restriction endonucleases. combination. Among them, a specific restriction endonuclease can cut the specific double probe strand and separate the double probe. In the process of DNA hybridization storage information reading, if the unseparated double probe strand is used directly, the detection signal will be wrong due to the existence of double fluorophores on the probe strand. When the method is implemented, a group is selected from the double-probe strand combination and sent to the data receiver, and the key (that is, the correct endonuclease information) is sent through another secret way. After receiving the key, the receiver can properly process the double-probe chain to separate the probes, but wrong processing will not be able to separate the probes, and may even cause the probes to self-destruct. The invention realizes the hard encryption of the DNA storage technology, can effectively improve the security, and promote the application of the storage technology.

Description

technical field [0001] The invention belongs to DNA storage technology, in particular to a hybrid storage encryption method for DNA information. Background technique [0002] DNA storage technology is the crystallization of the intersection of life science and information science. DNA is the genetic material selected in the long process of biological evolution. As an information storage material, DNA has the characteristics of extremely long storage time, huge storage information capacity, and strong environmental adaptability, and has great development potential. The current mainstream technology in the field of DNA storage is based on DNA synthesis and sequencing. Although this technology has high information density, it has weaknesses such as poor parallelism, long read and write time, and low encryption performance, which limit the practical application of DNA storage technology. To this end, the applicant team developed DNA hybridization storage technology in the previ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16B20/20G16B20/30G06F21/60
CPCG16B20/20G16B20/30G06F21/602
Inventor 肖祖颖张翼飞王海华赵椰成鹏飞刘翟
Owner HUNAN UNIV OF SCI & TECH
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