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DNA hybridization information storage encryption method based on double-probe specific separation

A technology of information storage and encryption method, applied in informatics, bioinformatics, genomics, etc., can solve the problem that DNA hybrid storage technology has not yet realized the encryption function, and achieve high security effects

Active Publication Date: 2021-09-03
HUNAN UNIV OF SCI & TECH
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Problems solved by technology

[0003] The technical problem to be solved by the present invention: Aiming at the problem that the existing DNA hybridization storage technology has not yet realized the encryption function, an encryption method for storing DNA hybridization information is provided. Encrypt the probes separately, and activate the probes by separating the double probes with a specific endonuclease, realizing a hard encryption method for DNA hybridization storage technology

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  • DNA hybridization information storage encryption method based on double-probe specific separation
  • DNA hybridization information storage encryption method based on double-probe specific separation

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Embodiment Construction

[0034] The method for storing and encrypting DNA information of the present invention will be further described in detail below by taking the writing target information "encryption" (two Chinese characters) as an example.

[0035] Such as figure 2 As shown, the DNA information storage parallel addressing writing method in this embodiment includes:

[0036] 1) Convert the target information, that is, the two Chinese characters "encryption" into binary code, 10111100110100111100001111011100 and divide it into 8 fields, each field corresponds to a data unit, including 4 binary digits;

[0037] 2) Map the 1 / 0 value on the 4 binary digits of each of the above fields to the presence / absence combination of the 4 DNA coding strands B1, B2, B3, and B4; for example, the first digit (corresponding to B1) has code chain, the value of this digit is 1, otherwise it is 0, and thus the list of code chains to be added to all data units on the DNA storage disk is obtained; taking the above 8 ...

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Abstract

The invention discloses a DNA storage encryption method based on double-probe specific separation. The DNA storage encryption method comprises a combination of a set of DNA double-probe chains with double fluorophores and restriction endonuclease recognition sites and restriction endonuclease. Wherein the specific restriction enzyme can be used for cutting the specific double-probe chain and separating the double probes. In a DNA hybridization storage information reading process, if unseparated double probe chains are directly used, detection signals are wrong due to existence of double fluorophores on the probe chains. When the method is implemented, one group of double-probe chain combination is selected from the double-probe chain combination to be sent to a data receiver, and a secret key (namely correct incision enzyme information) is sent through another secret path. After receiving the secret key, the method can correctly process the double-probe chain to separate the probes, but the probes cannot be separated if the probes are wrongly processed, and even self-destruction of the probes is possibly caused. The hard encryption of the DNA storage technology is achieved, safety can be effectively improved, and application of the storage technology is promoted.

Description

technical field [0001] The invention belongs to DNA storage technology, in particular to a DNA information hybrid storage encryption method. Background technique [0002] DNA storage technology is the crystallization of the cross fusion of life science and information science. DNA is the genetic material selected in the long process of biological evolution. As an information storage material, DNA has the characteristics of extremely long storage time, large storage information capacity, and strong environmental adaptability, and has great development potential. At present, the mainstream technology in the field of DNA storage is based on DNA synthesis and sequencing. Although this technology has high information density, it has weaknesses such as poor parallelism, long read and write time, and low encryption performance, which limits the practical application of DNA storage technology. To this end, the applicant team developed a DNA hybrid storage technology in its previous...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B20/20G16B20/30G06F21/60
CPCG16B20/20G16B20/30G06F21/602
Inventor 张翼飞王海华肖祖颖赵椰成鹏飞刘翟
Owner HUNAN UNIV OF SCI & TECH
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