Preparation method of novel nano preparation capable of treating brain glioma

Abstract

The invention discloses a preparation method of a novel nano preparation capable of treating brain glioma. The preparation method of the novel nano preparation capable of treating the brain glioma comprises the following steps of synthesizing an LAT1 targeting material, specifically, taking polyethylene glycol monostearate as a raw material, and synthesizing the LAT1 targeted material by connecting glutamic acid through esterification reaction; preparing a brain-targeted liposome based on LAT1, and modifying the surface of the liposome with an LAT1 targeted material to prepare the temozolomide entrapped liposome with a brain-targeted function. According to the preparation method of the novel nano preparation capable of treating the brain glioma, the LAT1 has high expression in brain cells and a blood brain barrier, and the targeting specificity is relatively strong; different from a conventional immune antigen protein receptor, a synthesized novel LAT1 active targeted material is characterized in that a substrate of the LAT1 is amino acid organic small molecules which are beneficial to active modification and have no immunogenicity; a good foundation is provided for an active targeting preparation of the LAT1; an active targeted liposome entraps temozolomide first-line treatment medicine, the unique advantage of active medicine loading can be achieved by applying the liposome, temozolomide molecules are wrapped in an inner water phase, the stability is good, and the entrapment efficiency is high.

Description

technical field [0001] The invention relates to the field of nano-preparation production, in particular to a method for preparing a novel nano-preparation capable of treating glioma. Background technique [0002] The current treatment methods for glioma are surgical resection and radiotherapy. The main goal of surgery is to resect the tumor while preserving nerve function, so as to achieve maximum safe resection. Glioma grows in an infiltrative manner, without a clear boundary with normal brain cells. Although it is difficult to remove, chemotherapy itself can induce "phenotype transformation", which is the transformation of non-tumor stem cells into tumor-producing cells. cells, a process that causes the cancer to come back again. Therefore, if a real-time imaging method can be used to distinguish the margins of normal brain tissue and glioma during the operation, and if other methods can be used to further kill the remaining cancer cells after resection, the success of th...

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Problems solved by technology

However, the endogenous synthetic capacity of tumor cells cannot meet the significantly increased demand

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