Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation for treating Parkinson's disease and application thereof

A Parkinson's disease and reagent technology, applied in the field of biomedicine, can solve the problems of poor specificity of dopamine D2 receptor agonists and limit the clinical use of dopamine receptor agonists, so as to achieve a good therapeutic effect of Parkinson's disease and improve motor coordination defects. Effect

Pending Publication Date: 2021-09-17
SOUTHERN MEDICAL UNIVERSITY
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the related art, dopamine receptor agonists have more side effects, such as causing upper gastrointestinal symptoms (loss of appetite, nausea, vomiting, etc.), circulatory system symptoms and central nervous symptoms, etc., and clinically common dopamine D2 Receptor agonists have poor specificity (such as Tazota, pramipexole), therefore, the actual clinical use of dopamine receptor agonists is greatly limited

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation for treating Parkinson's disease and application thereof
  • Preparation for treating Parkinson's disease and application thereof
  • Preparation for treating Parkinson's disease and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0080] In order to make the object, technical solution and technical effect of the present invention clearer, the present invention will be further described in detail below in conjunction with specific embodiments. It should be understood that the specific implementations described in this specification are only for explaining the present invention, not for limiting the present invention.

[0081] The experimental materials and reagents used, unless otherwise specified, are conventional consumables and reagents that can be obtained from commercial channels.

[0082] Experimental Materials

[0083] In the following examples of the present invention, the mice used are all male mice aged 8 to 14 weeks, with an average body weight of 22 to 26 g, and the mouse model strain is B6.129S4(FVB)-Drd2tm1.1Mrub / J( Drd2 loxp / loxp mouse), which was purchased from Jackson Laboratory, USA.

[0084] Cdc42 protein (amino acid sequence shown in SEQ ID NO.1);

[0085] A nucleic acid molecule ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation for treating Parkinson's disease and application thereof. In the preparation for treating the Parkinson's disease and the application thereof, an inventor constructs adeno-associated viruses efficiently infected with dopamine D2 receptor neurons, and injects the adeno-associated viruses into a striatum region of a mouse model with the Parkinson's disease by adopting a brain stereotactic injection mode, the adeno-associated viruses can significantly improve PD-related or D2R knockout-induced movement coordination defects, bradykinesia and recognition memory impairment by activating or continuously activating Cdc42, such that the good Parkinson's disease treatment effect is provided, and the important significance is provided for the development of the Parkinson's disease prevention and treatment drug.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a preparation for treating Parkinson's disease and its application. Background technique [0002] Parkinson's disease (PD) is currently the second most common degenerative neurological disease. Especially in the dorsal striatum) the level of dopamine (Dopamine, DA) is significantly reduced, which leads to the imbalance of the direct pathway expressing dopamine D1 receptors and the indirect pathway expressing dopamine D2 receptors in striatum, and then produces Parkinson's disease movement and Nonmotor dysfunction. [0003] Dopamine receptor agonists refer to drugs that can directly act on dopamine receptors and have disease-modifying effects. They are mainly used as co-administered drugs, which can prolong the curative effect, reduce the end-of-dose phenomenon, and delay the occurrence of dyskinesia. Common drug for patients with early-onset Parkinson's disease. However,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K38/17A61K48/00A61K45/00A61K45/06A61P25/16
CPCA61K38/1709A61K48/005A61K48/0008A61K45/00A61K45/06A61P25/16A61K2300/00
Inventor 张璐张琳应莉
Owner SOUTHERN MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com