Preparation for treating Parkinson's disease and application thereof

A Parkinson's disease and reagent technology, applied in the field of biomedicine, can solve the problems of poor specificity of dopamine D2 receptor agonists and limit the clinical use of dopamine receptor agonists, so as to achieve a good therapeutic effect of Parkinson's disease and improve motor coordination defects. Effect

Pending Publication Date: 2021-09-17
SOUTHERN MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the related art, dopamine receptor agonists have more side effects, such as causing upper gastrointestinal symptoms (loss of appetite, nausea, vomiting, etc.), circulatory system symptoms and central

Method used

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  • Preparation for treating Parkinson's disease and application thereof
  • Preparation for treating Parkinson's disease and application thereof
  • Preparation for treating Parkinson's disease and application thereof

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Embodiment Construction

[0080] In order to make the object, technical solution and technical effect of the present invention clearer, the present invention will be further described in detail below in conjunction with specific embodiments. It should be understood that the specific implementations described in this specification are only for explaining the present invention, not for limiting the present invention.

[0081] The experimental materials and reagents used, unless otherwise specified, are conventional consumables and reagents that can be obtained from commercial channels.

[0082] Experimental Materials

[0083] In the following examples of the present invention, the mice used are all male mice aged 8 to 14 weeks, with an average body weight of 22 to 26 g, and the mouse model strain is B6.129S4(FVB)-Drd2tm1.1Mrub / J( Drd2 loxp / loxp mouse), which was purchased from Jackson Laboratory, USA.

[0084] Cdc42 protein (amino acid sequence shown in SEQ ID NO.1);

[0085] A nucleic acid molecule ...

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Abstract

The invention discloses a preparation for treating Parkinson's disease and application thereof. In the preparation for treating the Parkinson's disease and the application thereof, an inventor constructs adeno-associated viruses efficiently infected with dopamine D2 receptor neurons, and injects the adeno-associated viruses into a striatum region of a mouse model with the Parkinson's disease by adopting a brain stereotactic injection mode, the adeno-associated viruses can significantly improve PD-related or D2R knockout-induced movement coordination defects, bradykinesia and recognition memory impairment by activating or continuously activating Cdc42, such that the good Parkinson's disease treatment effect is provided, and the important significance is provided for the development of the Parkinson's disease prevention and treatment drug.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a preparation for treating Parkinson's disease and its application. Background technique [0002] Parkinson's disease (PD) is currently the second most common degenerative neurological disease. Especially in the dorsal striatum) the level of dopamine (Dopamine, DA) is significantly reduced, which leads to the imbalance of the direct pathway expressing dopamine D1 receptors and the indirect pathway expressing dopamine D2 receptors in striatum, and then produces Parkinson's disease movement and Nonmotor dysfunction. [0003] Dopamine receptor agonists refer to drugs that can directly act on dopamine receptors and have disease-modifying effects. They are mainly used as co-administered drugs, which can prolong the curative effect, reduce the end-of-dose phenomenon, and delay the occurrence of dyskinesia. Common drug for patients with early-onset Parkinson's disease. However,...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61K48/00A61K45/00A61K45/06A61P25/16
CPCA61K38/1709A61K48/005A61K48/0008A61K45/00A61K45/06A61P25/16A61K2300/00
Inventor 张璐张琳应莉
Owner SOUTHERN MEDICAL UNIVERSITY
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