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Application of Tanreqing in preparation of anti-influenza virus medicine

An anti-influenza virus, Tanreqing technology, applied in antiviral agents, drug combinations, pharmaceutical formulas, etc., can solve the problems of anti-influenza virus that have not yet been prepared by Tanreqing preparations, and achieve the goal of inhibiting lung pathological damage and slowing down death Effect

Pending Publication Date: 2022-02-01
SHANGHAI KAIBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no relevant report on the use of Tanreqing preparations for anti-influenza virus

Method used

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  • Application of Tanreqing in preparation of anti-influenza virus medicine
  • Application of Tanreqing in preparation of anti-influenza virus medicine
  • Application of Tanreqing in preparation of anti-influenza virus medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0033] In order to evaluate the therapeutic effects of Tanreqing Capsules and Tanreqing Injection on influenza virus-induced diseases, the following experiments are now carried out:

[0034] (1) Materials and instruments

[0035] 1.1 Materials

[0036] 1.1.1 Reagent

[0037] Tanreqing Capsules, batch number: 2003108; production date: 20200319; concentration: 1410mg / kg, 470mg / kg, 160mg / kg;

[0038] Tanreqing injection, batch number: 2003206; production date: 20200306; concentration: 7.8mg / kg, 2.6mg / kg, 0.87mg / kg;

[0039] 1.1.2 Experimental animals

[0040] Balb / C mice, grade: SPF grade; age: 6-8 weeks; source: Shanghai Lingchang Biotechnology Co., Ltd.; certificate: 2013001832987;

[0041] 1.1.3 Types of viruses

[0042] Influenza A H1N1-FM1 / 47 murine lung-adapted strain, source: ATCC;

[0043] 1.2 Instruments

[0044] Ultra-low temperature refrigerator (Thermo), IVC system (Jiangsu Fengshi);

[0045] (2) Experimental process

[0046] 2.1 Experimental drug preparation...

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Abstract

The invention relates to an application of Tanreqing in preparation of an anti-influenza virus medicine. In an influenza virus infected mouse model, the treatment effect and the treatment effect of a Tanreqing capsule and a Tanreqing injection on influenza virus induced diseases are evaluated, and the result shows that the Tanreqing capsule and the Tanreqing injection have the obvious effects of inhibiting virus induced lung pathological injury and slowing down virus infected mouse death.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to the application of Tanreqing in the preparation of anti-influenza virus drugs. Background technique [0002] Tanreqing is composed of Scutellaria baicalensis, bear bile powder, goat horn, honeysuckle and forsythia. It is mainly used to treat pneumonia, bronchitis attack, lung abscess and wind-heat cold. [0003] However, there is a big difference between Fengreganmao in the traditional Chinese medicine system and influenza in the Western medicine system. Patients with Fengreganmao mainly present with fever and mild aversion to cold, accompanied by cold symptoms, prone to cough, nasal congestion, runny Yellow nose, sticky, and yellow sputum; Influenza often has a rapid onset, with severe systemic symptoms and mild respiratory symptoms. Patients will have symptoms such as chills and high fever, and their body temperature can reach 39 When the temperature reac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/355A61K36/539A61K36/634A61P11/00A61P31/16A61K35/32A61K35/413
CPCA61K36/539A61K35/413A61K35/32A61K36/355A61K36/634A61P11/00A61P31/16A61K2300/00
Inventor 张小利穆竟伟王国明许露
Owner SHANGHAI KAIBAO PHARMA
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