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A composition and technology of scorpion venom peptide are applied in the field of pharmaceutical preparation and achieve the effects of good safety, stable quality and improved product stability
Pending Publication Date: 2022-02-11
上海万锦医药科技有限公司
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Problems solved by technology
In the prior art, there is no report on the pharmaceutical composition containing SVHRSP scorpion venom peptide. Therefore, it is particularly important to develop a stable and long-term storage pharmaceutical composition containing SVHRSP scorpion venom peptide
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Embodiment 1
[0026] Example 1 The study of the pH of the pharmaceutical composition containing SVHRSP scorpion venom peptide
[0027] 1. Preparation prescription and preparation process
[0028] Weigh 37g of mannitol and 3g of m-cresol, add them to 800mL of water for injection, stir and mix evenly, add 15g of SVHRSP scorpion venom peptide, after the main drug is completely dissolved, add water for injection to prepare 1L. Divide the liquid medicine into 5 equal parts, and each part has 3 groups of parallel experiments, adjust the pH to 3.5, 3.8, 4.0, 4.2, 4.5 with sodium hydroxide solution, filter them with 0.22 μm sterile filters, and transfer these solutions to In a 15 mL glass vial with screw cap.
[0029] 2. Test method
[0030] (1) High temperature test
[0031] The test product was placed in a sealed clean container, placed at 40°C for 10 days, and samples were taken on the 10th day to detect relevant indicators.
[0032] (2) Light exposure test
[0033] The test product is plac...
Embodiment 2
[0044] Example 2 Research on the osmotic pressure regulator of the pharmaceutical composition containing SVHRSP scorpion venom 1, preparation prescription and preparation process
Embodiment 21
[0046] SVHRSP Scorpion Venom Peptide 15g Sodium chloride 9g m-cresol 3g sodium hydroxide Adjust pH to 4.0 Add water for injection to 1L
[0047] Weigh the prescribed amount of sodium chloride and m-cresol, add it to 800mL of water for injection, stir and mix evenly, add the prescribed amount of SVHRSP scorpion venom peptide, after the main drug is completely dissolved, adjust the pH to 4.0 with sodium hydroxide, and add water for injection to 1 L, filter through a 0.22 μm sterile filter, and transfer to a 15 mL glass vial with a screw cap.
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Abstract
The invention belongs to the technical field of medicine preparation, and discloses a medicinal composition containing SVHRSP scorpion venom peptide, and a preparation method thereof. The medicinal composition comprises the SVHRSP scorpion venom peptide with the effective treatment amount or pharmaceutically acceptable salt of the SVHRSP scorpion venom peptide and a pharmaceutically acceptable carrier, and the pharmaceutically acceptable carrier comprises a pH regulator, an osmotic pressure regulator and a preservative. The content of related substances and SVHRSP scorpion venom peptide is not obviously changed within two years of storage of the medicinal composition prepared by the invention, the quality is stable and controllable, the safety is good, and the medicinal composition can be used for clinical injection.
Description
technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a medicine composition containing SVHRSP scorpion venom peptide and a preparation method thereof. Background technique [0002] Buthusmartensi iKarsch (BmK), BmK is also known as Buthus martensi iKarsch, a traditional Chinese medicine. Modern medical research has proved that its function is that the scorpion venom (Scorpion Venom, SV) SV released by the venom gland of the scorpion tail has a variety of therapeutic effects. , but the severe neurotoxicity has greatly restricted its development and application. my country has isolated and purified BmK scorpion venom with anti-tumor, anti-pain, anti-epilepsy, anti-thrombotic, anti-inflammatory, anti-rheumatic, antibacterial and other functions. of scorpion venom. [0003] Chinese invention patent application CN1324621A discloses an effective scorpion venom that can eliminate the neurotoxicity of Bmk while maintaining its ...
Claims
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