8 results about "Scorpion Venoms" patented technology

The invention discloses a method for detecting scorpion venom-induced cardiotoxicity by fusing metabonomics and an ultrasonic electrocardiogram, the ultrasonic electrocardiogram proves that scorpion venom has cardiotoxicity, then the change of metabolites related to cardiotoxicity is researched through serum metabonomics, and 37 different metabolites are screened out. The kit can find potential damage of scorpion venom to the heart at an early stage, has relatively high sensitivity and specificity, solves the technical problems of high sampling difficulty in traditional pathology, low sensitivity, poor specificity and long period of conventional markers, remarkably improves the timeliness and reliability of scorpion venom cardiotoxicity prediction, and has a good application prospect. And a scientific basis is provided for subsequent preclinical safety evaluation and clinical medication monitoring of scorpion venom preparations.

The invention discloses a medicine for treating diabetic retinopathy and application of scorpion venom heat-resistant synthetic peptide in treating the disease, belongs to the field of research and development of polypeptide medicines, and is used for treating or preventing the diabetic retinopathy (DR). Experimental results show that the scorpion venom heat-resistant synthetic peptide (SVHRSP) has the effect of preventing and treating diabetic retinopathy (DR) on a streptozotocin (STZ)-induced mouse experimental diabetes model, and can repress retinal function impairment caused by impairment of streptozotocin (STZ)-induced diabetic mouse retinal photoreceptor cells and retinal nerve inner layer cells; and retina structure damage caused by thinning of the retina thickness of a diabetic mouse induced by STZ (streptozotocin) is inhibited.

The invention relates to a composition used as an anti-carcinogenic agent having low cardiotoxicity and high antimicrobial stability. The composition comprises at least one fraction of Heteroctenus junceus scorpion venom, wherein said fraction can be selected from the list comprising: F4, F5.3 and any recognisable and identifiable combination of the two, wherein both fractions have an anti-carcinogenic effect, which is mainly associated with the total or partial inhibition of tumour progression.

This invention discloses the application of the scorpion venom polypeptide BmK AS in the treatment of chronic epilepsy. BmK AS exerts potent anti-epileptic and neuroprotective effects through a confluence mechanism. In a lycine-induced mouse model, BmK AS significantly shortened seizure duration, reduced seizure frequency, prolonged seizure latency, and improved cognitive and mental outcomes. Electrophysiologically, BmK AS nonlinearly inhibited multiple VGSC subtypes, with a particularly significant effect on Nav1.6, reducing peak sodium current by 43% at a concentration of 5 nM. Furthermore, BmK AS alleviated hippocampal neuroinflammation by inhibiting the NLRP1 inflammasome pathway and related pyroptosis. This invention establishes BmK AS as a promising multi-mechanism therapeutic candidate, highlighting the value of a dual therapeutic strategy of Nav1.6 blockade and neuroinflammation suppression for epilepsy treatment.

The invention discloses an automatic scorpion venom collection terminal which comprises a shell, a meat tube, a sensor, a venom flow guide tube, a venom storage cavity and a bionic vibration unit, the automatic scorpion venom collection terminal does not comprise an external control system, the bionic vibration unit is in butt joint with an external vibration source through two power lines, and scorpions are attracted to find food in a vibration and smell mode; a plurality of openings are formed in the shell and allow scorpion poison thorns to pierce, venom storage cavities made of bionic skin are formed in the openings of the shell, sensors are arranged on the edges of the openings of the shell and can sense piercing of the poison thorns and send out interrupt signals, and after the poison thorns pierce, the meat custard can flow out of the meat custard tube to reward scorpions. The venom flow guide pipe is composed of a liquid inlet and a liquid outlet, purified water flows into the liquid inlet to wash venom, and then the venom flows out of the liquid outlet; the external control system at least comprises receiving interruption, providing a vibration source, controlling the vibration time, controlling the meat custard tube to flow out of the meat custard, closing the meat custard tube, displaying the interruption frequency and controlling the venom flow guide tube to lead out venom.

The application discloses a scorpion venom collecting device, and mainly relates to the technical field of scorpion venom collection. The device comprises a plurality of collecting boxes arranged on a box body and used in cooperation with scorpions, the two ends of the collecting box are respectively provided with an entrance and an exit for the scorpions to enter and exit, and a collecting cavity connected with the entrance and the exit, the collecting box is slidably connected with an upper clamping block and a lower clamping block, the upper clamping block and the lower clamping block are respectively in contact with the scorpions, a push block is transversely slidably connected to the collecting box, the end of the push block is vertically slidably connected with a sliding block, the end of the sliding block is rotatably connected with a roller in rolling contact with the scorpions, the collecting box is provided with a liquid taking channel in communication with the collecting cavity, the upper clamping block is provided with a first electrode in contact with the scorpions, and the collecting box is provided with a second electrode in contact with the scorpions. The application has the advantages that the problem that the scorpions cannot be effectively fixed is solved, and the safety and efficiency of collecting the scorpion venom are improved.

Provided are a new venom polypeptide-dendrimer complex, and a preparation method therefor and the use thereof. Specifically, provided is a scorpion venom polypeptide, wherein the amino acid sequence of the scorpion venom polypeptide is FLGGLLSSIF. A new scorpion venom polypeptide (designated as C9) is isolated and identified. Moreover, a new polypeptide-polyamidoamine dendrimer complex G5C9 (i.e., nanoparticles) having a glioblastoma (GBM)-targeting effect is constructed. Compared with polypeptide C9, G5C9 exhibits significantly improved cellular uptake efficiency. G5C9 can enter cells via endocytosis and targets lysosomes, and inhibits lysosomal function and mTORC1, thereby promoting nuclear translocation of TFEB and further inducing autophagic cell death. Therefore, G5C9 provides a new targeted anti-GBM approach both in vitro and in vivo.

The application discloses a scorpion venom freeze-drying device and belongs to the field of medicinal liquor production. The device comprises a freezing box, a containing box connected in the freezing box, a refrigeration sheet arranged at the bottom of the containing box, a planing frame horizontally and slidably connected to the upper end of the containing box, and a planing blade connected to the planing frame. A rectangular plate is vertically and slidably connected to the bottom of the containing box. When the rectangular plate moves upwards, the frozen scorpion venom is pushed upwards. When the frozen scorpion venom moves upwards, the planing frame moves horizontally and reciprocally, so that the planing blade planes the frozen scorpion venom into ice chips. After the scorpion venom is frozen, the freezing box is vacuumized, the rectangular plate is controlled to move upwards, and the planing frame is controlled to move horizontally and reciprocally. When the frozen scorpion venom is pushed upwards by the rectangular plate, the planing blade connected to the planing frame that moves horizontally and reciprocally planes the lifted frozen scorpion venom into ice chips, improves the surface area, and thus the sublimation speed of the water in the subsequent ice chips is improved.