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Polyphenol multi-element cyclodextrin inclusion compound for reducing uric acid and preparation method thereof

A cyclodextrin inclusion complex and uric acid-lowering technology, applied in the fields of medicines and health care products, can solve problems such as no literature reports, and achieve the effects of reducing reabsorption, reducing blood uric acid, and improving bioavailability

Pending Publication Date: 2022-02-11
SHENYANG WANJIA INST OF BIOLOGICAL TECH RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, there are no literature reports on quercetin, dihydromyricetin, kudzu flavonoids, tea polyphenols, chrysanthemum flavonoids and their clathrates for lowering uric acid and anti-gout

Method used

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  • Polyphenol multi-element cyclodextrin inclusion compound for reducing uric acid and preparation method thereof
  • Polyphenol multi-element cyclodextrin inclusion compound for reducing uric acid and preparation method thereof
  • Polyphenol multi-element cyclodextrin inclusion compound for reducing uric acid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The uric acid-lowering polyphenol polycyclodextrin inclusion compound of the present invention is prepared from the following raw materials according to the stated parts by weight: 2 parts of quercetin, 1 part of dihydromyricetin, 1 part of Pueraria flavonoids, tea 1 part of polyphenols, 0.5 parts of chrysanthemum flavonoids, 10 parts of β-cyclodextrin, and 15 parts of mannitol.

[0032] The preparation method comprises the following steps: weighing 2 parts by weight of quercetin, 1 part by weight of dihydromyricetin, 1 part by weight of kudzu flavonoids, 1 part by weight of tea polyphenols, 0.5 parts by weight of chrysanthemum flavonoids and 10 parts by weight of beta-cyclodextrin , add water 3 times the weight of the total amount of the above materials and stir evenly, then pour it into the colloid mill, and grind the colloid mill for 25 minutes to obtain the polyphenol polycyclodextrin inclusion compound solution, which is set aside; take 15 parts by weight of mannito...

Embodiment 2

[0035] The uric acid-lowering polyphenol polycyclodextrin inclusion compound of the present invention is prepared from the following raw materials according to the stated parts by weight: 2 parts of quercetin, 1.8 parts of dihydromyricetin, 1 part of Pueraria flavonoids, tea 0.5 parts of polyphenols, 0.6 parts of chrysanthemum flavonoids, 12 parts of β-cyclodextrin, and 12 parts of mannitol.

[0036] The preparation method comprises the following steps: weighing 2 parts by weight of quercetin, 1.8 parts by weight of dihydromyricetin, 1 part by weight of puerarin flavonoids, 0.5 parts by weight of tea polyphenols, 0.6 parts by weight of chrysanthemum flavonoids and 12 parts by weight of beta-cyclodextrin , add 2.5 times the weight of water of the total amount of the above materials and stir evenly, then pour it into the colloid mill, and the colloid mill grinds for 20 minutes to obtain the polyphenol polycyclodextrin inclusion compound solution, which is for subsequent use; 12 p...

Embodiment 3

[0039] The uric acid-lowering polyphenol polycyclodextrin inclusion compound of the present invention is prepared from the following raw materials according to the stated parts by weight: 2 parts of quercetin, 1.2 parts of dihydromyricetin, 0.8 parts of kudzu root flavonoids, tea 0.8 parts of polyphenols, 0.7 parts of chrysanthemum flavonoids, 15 parts of β-cyclodextrin, and 14 parts of mannitol.

[0040] The preparation method comprises the following steps: weighing 2 parts by weight of quercetin, 1.2 parts by weight of dihydromyricetin, 0.8 parts by weight of puerarin flavonoids, 0.8 parts by weight of tea polyphenols, 0.7 parts by weight of chrysanthemum flavonoids and 15 parts by weight of beta-cyclodextrin , add 2 times the weight of water of the total amount of the above materials and stir evenly, then pour it into the colloid mill, and grind the colloid mill for 28 minutes to obtain the polyphenol polycyclodextrin inclusion compound solution, which is set aside; take 14 ...

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Abstract

The invention relates to a polyphenol multi-element cyclodextrin inclusion compound for reducing uric acid and a preparation method thereof, and belongs to the technical field of medicine and health care products. The polyphenol multi-element cyclodextrin inclusion compound is prepared from the following raw materials in parts by weight: 2 parts of quercetin, 0.5 to 2 parts of dihydromyricetin, 0.5 to 2 parts of pueraria flavone, 0.5 to 2 parts of tea polyphenol, 0.2 to 1 part of chrysanthemum flavone, 5 to 15 parts of beta-cyclodextrin and 10 to 15 parts of mannitol. The invention aims to provide the polyphenol multi-element cyclodextrin inclusion compound capable of reducing uric acid and the preparation method thereof, which is capable of reducing uric acid can well inhibit xanthine oxidase and promote uric acid excretion, has a good anti-inflammatory effect, and has relatively strong effects of reducing uric acid and resisting gout.

Description

technical field [0001] The invention relates to a uric acid-lowering polyphenol multi-cyclodextrin inclusion compound and a preparation method thereof. The inclusion compound has good therapeutic and health care effects on diseases such as hyperuricemia and gout, and belongs to the technical field of medicines and health products . Background technique [0002] With the improvement of modern people's living standards, great changes have taken place in diet, and the prevalence of hyperuricemia and gouty arthritis is increasing. The data recorded by the National Rheumatology Data Center shows that gout patients in my country are showing a trend of younger age and higher incidence. [0003] Literature research shows that hyperuricemia and gout are mainly caused by increased uric acid production and decreased uric acid excretion, because adenosine deaminase (ADA) and xanthine oxidase (XOD) can promote hypoxanthine to xanthine and uric acid Transformation, when adenosine deamin...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K36/82A61P19/06A23L33/105A23L33/125A23P10/30A61K31/352A61K31/353
CPCA61K47/6951A61K31/352A61K36/488A61K36/82A61K31/353A61K36/287A61P19/06A23L33/105A23L33/125A23P10/30A23V2002/00A61K2300/00A23V2200/30A23V2250/21168A23V2250/2116A23V2250/2132A23V2250/214A23V2250/5112A23V2250/6418Y02A50/30
Inventor 董英杰艾莉李晓怡邹晓峰丁爽韩亚男
Owner SHENYANG WANJIA INST OF BIOLOGICAL TECH RES
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