Letrozole-containing vaginal ring as well as preparation method and application thereof
A technology of vaginal ring and letrozole, applied in the field of medical equipment
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Embodiment 1
[0041] Example 1: Preparation of vaginal ring (1 month)
[0042] Letrozole 300mg
[0043] Pluronic-188 50mg
[0044] Silicone rubber LS-4100 3g
[0045]Letrozole and Pluronic-188 are coupled and mixed evenly with silicone rubber in the rubber mixer, and injected into the mold through a special extruder for silicone rubber to be heated and formed.
[0046] Dissolve 0.5 g of silicone rubber in 10 g of n-hexane, and evenly coat a film of 0.02 mm on the outer layer of the above-mentioned formed vaginal ring by the method of coating.
Embodiment 2
[0047] Embodiment 2: the preparation of vaginal ring (60 days)
[0048] Letrozole 400mg
[0049] Sodium Lauryl Sulfate 100mg
[0050] Silicone rubber MDX-4200 3g
[0051] After letrozole is coupled with sodium lauryl sulfate, it is evenly mixed with silicone rubber in a rubber mixer, and injected into a mold by a special extruder for silicone rubber to be heated and formed.
[0052] Dissolve 0.5 g of silicone rubber in 10 g of n-hexane, and evenly coat a film of 0.05 mm on the outer layer of the formed vaginal ring by the method of coating.
Embodiment 3
[0053] Embodiment 3: the preparation of vaginal ring (60 days)
[0054] Letrozole 400mg
[0055] Fatty acid polyglycerides 100mg
[0056] Silicone rubber Q7-4840 3g
[0057] Letrozole is coupled with polyglycerol fatty acid ester and mixed evenly with silicone rubber in a rubber mixer, and injected into a mold by a special extruder for silicone rubber to be heated and formed.
[0058] Dissolve 0.5 g of silicone rubber in 10 g of n-hexane, and evenly coat a film of 0.1 mm on the outer layer of the formed vaginal ring by the method of coating.
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