Letrozole-containing vaginal ring as well as preparation method and application thereof

A technology of vaginal ring and letrozole, applied in the field of medical equipment

Inactive Publication Date: 2022-02-22
上海市生物医药技术研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term use of trazole after breast cancer surgery generally lasts up to 5 years

Method used

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  • Letrozole-containing vaginal ring as well as preparation method and application thereof
  • Letrozole-containing vaginal ring as well as preparation method and application thereof
  • Letrozole-containing vaginal ring as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1: Preparation of vaginal ring (1 month)

[0042] Letrozole 300mg

[0043] Pluronic-188 50mg

[0044] Silicone rubber LS-4100 3g

[0045]Letrozole and Pluronic-188 are coupled and mixed evenly with silicone rubber in the rubber mixer, and injected into the mold through a special extruder for silicone rubber to be heated and formed.

[0046] Dissolve 0.5 g of silicone rubber in 10 g of n-hexane, and evenly coat a film of 0.02 mm on the outer layer of the above-mentioned formed vaginal ring by the method of coating.

Embodiment 2

[0047] Embodiment 2: the preparation of vaginal ring (60 days)

[0048] Letrozole 400mg

[0049] Sodium Lauryl Sulfate 100mg

[0050] Silicone rubber MDX-4200 3g

[0051] After letrozole is coupled with sodium lauryl sulfate, it is evenly mixed with silicone rubber in a rubber mixer, and injected into a mold by a special extruder for silicone rubber to be heated and formed.

[0052] Dissolve 0.5 g of silicone rubber in 10 g of n-hexane, and evenly coat a film of 0.05 mm on the outer layer of the formed vaginal ring by the method of coating.

Embodiment 3

[0053] Embodiment 3: the preparation of vaginal ring (60 days)

[0054] Letrozole 400mg

[0055] Fatty acid polyglycerides 100mg

[0056] Silicone rubber Q7-4840 3g

[0057] Letrozole is coupled with polyglycerol fatty acid ester and mixed evenly with silicone rubber in a rubber mixer, and injected into a mold by a special extruder for silicone rubber to be heated and formed.

[0058] Dissolve 0.5 g of silicone rubber in 10 g of n-hexane, and evenly coat a film of 0.1 mm on the outer layer of the formed vaginal ring by the method of coating.

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Abstract

The invention relates to a vaginal ring for treating breast cancer and/or atypical endometrial thickening. The vaginal ring comprises a drug-containing part and a silicone rubber layer coating the drug-containing part, the drug-containing part comprises the following components in percentage by weight: 5-60% of letrozole, 0.5-20% of a physiologically acceptable surfactant and the balance of silicone rubber according to the total weight of the drug-containing part; and the thickness of the silicon rubber layer coated on the medicine-containing part is 0.02 to 1 mm. The invention further relates to application of the vaginal ring in preparation of a medicine for treating breast cancer and/or atypical endometrial thickening.

Description

technical field [0001] The present invention relates to the field of medical devices, specifically, the present invention relates to a vaginal ring containing letrozole; the invention also relates to a preparation method of the vaginal ring; Type of endometrial thickening product application. Background technique [0002] The female mammary gland is composed of skin, fibrous tissue, mammary glands and fat. Breast cancer is a malignant tumor that occurs in the mammary gland epithelial tissue. The mammary gland is not an important organ to maintain human life activities, and breast cancer in situ is not fatal; but because breast cancer cells lose the characteristics of normal cells, the connections between cells are loose and easy to fall off. Once the cancer cells fall off, the free cancer cells can spread throughout the body with the blood or lymph fluid, forming metastasis, which is life-threatening. At present, breast cancer has become a common tumor that threatens women...

Claims

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Application Information

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IPC IPC(8): A61L31/16A61L31/10A61L31/06A61K9/00A61K31/4196A61K47/34A61M31/00A61P15/00A61P35/00
CPCA61L31/16A61L31/06A61L31/10A61M31/002A61K31/4196A61K9/0034A61K47/34A61P35/00A61P15/00A61M2210/1475A61L2300/204A61L2300/606A61L2300/416A61M2210/005C08L83/04
Inventor 邵海浩
Owner 上海市生物医药技术研究院
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