Establishment method and application of prognostic marker and prognostic risk assessment model of squamous cell carcinoma

Abstract

The invention discloses a prognostic marker of squamous cell carcinoma, an establishment method of a prognostic risk assessment model and application of the prognostic marker and the prognostic risk assessment model, compared with single gene expression detection of squamous cell carcinoma in the prior art, the prognostic marker and the prognostic risk assessment model have higher specificity and higher diagnosis efficiency, can remarkably improve the detection sensitivity and specificity, and can be used for detecting squamous cell carcinoma. The method can accurately, conveniently and efficiently provide effective treatment measures for squamous cell carcinoma patients and improve prognosis, has good clinical application value, has the advantages of high sensitivity, good specificity and high accuracy, can provide effective guidance for clinicians to make treatment decisions on the squamous cell carcinoma patients, reduces the occurrence of invalid treatment, and has a wide application prospect. Therefore, treatment cost and discomfort experience of patients are reduced, long-term prognosis of squamous cell carcinoma patients can be improved, and social disease burden is expected to be relieved.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a squamous cell carcinoma prognostic marker, a method for establishing a prognostic risk assessment model and an application thereof. Background technique [0002] Squamous cell carcinoma is a histological type of common malignant tumors that seriously threaten human health. Common squamous cell carcinomas include lung squamous cell carcinoma, head and neck squamous cell carcinoma, esophageal squamous cell carcinoma and cervical cancer. These squamous cell carcinomas seriously endanger human health and life, and the global death toll exceeds 1 million every year. TP63 and SOX2 are the main transcription factors that promote squamous cell carcinogenesis, and are highly amplified in squamous cell carcinoma cells. Although there are many mature treatment methods applied to squamous cell carcinoma, such as chemotherapy, radiotherapy and immunotherapy, etc., the long-term survival rate of ...

AI Technical Summary

Problems solved by technology

However, this marker is relatively single, with only one gene as a marker, the technical specificity and sensitivity are not high, and the detection method is unstable and expensive

[0006] In the prior art, a single gene as a biomarker is not sensitive and accurate enough for predicting the prognosis of squamous cell carcinoma, and its diagnostic efficiency is low; traditional serum tumor markers are limited in the early diagnosis of squamous cell carcinoma due to their low sensitivity and specificity. The ability is also limited, and most of the markers in the prior art can only predict the prognosis of one type of squamous cell carcinoma

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