Application of K786-4469 compound in preparation of antitumor drugs

An anti-tumor drug and compound technology, applied in the field of biomedicine, can solve the problems of unsatisfactory prognosis and esophageal cancer with K786-4469 compound, and achieve the effect of inhibiting migration and invasion.

Pending Publication Date: 2022-04-01
GUANGZHOU MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

According to statistics, the 5-year survival rate of ESCC in my country has increased from about 20% to about 30% in the past ten years, but the overall prognosis is still unsatisfactory, and tumor migration and invasion are the main factors for treatment failure.
So far, there is no relevant report about the use of K786-4469 compound in the treatment of esophageal cancer

Method used

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  • Application of K786-4469 compound in preparation of antitumor drugs
  • Application of K786-4469 compound in preparation of antitumor drugs
  • Application of K786-4469 compound in preparation of antitumor drugs

Examples

Experimental program
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Effect test

Embodiment 1

[0022] Embodiment 1: in vitro experiment

[0023] 4.1 Experimental materials

[0024] Human esophageal cancer T.TN cells and esophageal squamous cell carcinoma KYSE270 cells were purchased from ATCC; the molecular structural formula of K786-4469 compound is as follows: figure 1 As shown, the K786-4469 compound was purchased from Shanghai Taosu Biochemical Technology Co., Ltd.; the CCK-8 kit was purchased from the Tongren Institute of Chemistry in Japan; the total cholesterol assay kit (enzyme colorimetric method) was purchased from Beijing Prilai Gene Technology Co., Ltd.; female nude mice (NOD-Prkdcem26Cd52ll2rgem26Cd22 / NjuCrl) were purchased from the Institute of Model Animals, Nanjing University; RPMI1640 medium, PBS buffer, fetal bovine serum, penicillin-streptomycin were purchased from Gibco, USA; DMSO Purchased from Sigma, USA. The K786-4469 compound was dissolved in DMSO, and stored at a concentration of 10 mM in a -80°C refrigerator. Before use, the concentration of ...

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Abstract

The invention discloses an application of a K786-4469 compound in preparation of an anti-tumor drug. Belongs to the technical field of biological medicine. And the concentration of the K786-4469 compound is 10 to 40 [mu] M. The molecular formula structural formula of the K786-4469 compound is as shown in a formula (I) in the specification. Experiments prove that the K786-4469 compound disclosed by the invention can be used for remarkably inhibiting migration and invasion of esophageal cancer cells.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and particularly relates to the application of K786-4469 compound in the preparation of antitumor drugs. Background technique [0002] Esophageal cancer is a common malignant tumor of the digestive tract, and its morbidity and mortality rank seventh and sixth among all malignant tumors, respectively. In recent years, with the improvement of medical level, the diagnosis and treatment of esophageal cancer have also made great progress. Esophageal squamous cell carcinoma (ESCC), as one of the histological subtypes of esophageal cancer, accounts for more than 90% of esophageal cancer in China. According to statistics, the 5-year survival rate of ESCC in my country has increased from about 20% to about 30% in the past ten years, but the overall prognosis is still unsatisfactory, and tumor migration and invasion are the main factors for treatment failure. At present, there is no relevant report a...

Claims

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Application Information

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IPC IPC(8): A61K31/454A61P35/00A61P35/04A61P1/00
CPCY02A50/30
Inventor 许雯雯李斌刘琴文张国庚
Owner GUANGZHOU MEDICAL UNIV
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