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Application of phthalic acid in promotion of hair growth

A hair growth and ophthalmic acid technology, applied in the field of medicine, can solve problems such as the application of ophthalmic acid that has not been publicly reported in the literature, and achieve the effect of promoting hair health and growth, good safety, and broad application prospects

Active Publication Date: 2022-04-19
CHINA PHARM UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 3-(2-Carboxybenzoyl)-oleanolic acid (oxalic acid, QTS) is an oleanolic acid derivative obtained by introducing phthalic acid at the hydroxyl site of oleanolic acid (OA), It belongs to pentacyclic triterpene derivatives. So far, there is no public report on the application of phthalic acid in hair loss and hair growth.

Method used

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  • Application of phthalic acid in promotion of hair growth
  • Application of phthalic acid in promotion of hair growth
  • Application of phthalic acid in promotion of hair growth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Experimental evaluation of the curative effect of phthalic acid on the natural hair growth model of C57BL / 6JNifdc mice

[0033] 1. Experimental animals

[0034] The experimental animals were female C57BL / 6JNifdc mice, 8 weeks old, weighing 18-20 g, purchased from Zhejiang Weitong Lihua Experimental Animal Technology Co., Ltd. C57BL / 6JNifdc mice were reared under normal conditions, with a temperature of 25 ± 2°C, a humidity of 50%-70%, alternating light and darkness for 12 hours each, free to eat and drink, and change the corncob litter every two days until they adapt The experiments were started after 7 days in the rearing environment.

[0035] 2. Drug configuration

[0036] (1) 2.5% tribromoethanol: 1g 2,2,2-tribromoethanol, 630μL tert-amyl alcohol, 40mL normal saline, mix in the dark for 12 hours, wait for complete dissolution, prepare 2.5% tribromoethanol solution, keep away from room temperature light save.

[0037] (2) 0.2% minoxidil: Weigh a certain amount of ...

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Abstract

The invention discloses an application of phthalic acid in hair growth promotion. The phthalic acid can be used as a unique active component for preparing a medicine or a reagent for promoting hair growth. The phthalic acid is an oleanolic acid derivative and belongs to a pentacyclic triterpenoid derivative, experiments prove that the phthalic acid group has a promoting effect on mouse hair growth, and hair growth is rapid; the invention provides a new application of the phthalic acid in promoting hair growth, and active ingredients of the phthalic acid are high in safety and small in toxic and side effects, so that the phthalic acid has a wide application prospect in the fields of pharmaceutical preparations, cosmetics, care products, beauty products and the like for preventing, nursing and treating less hair and alopecia and promoting hair health and growth.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the application of phthalic acid in promoting hair growth. Background technique [0002] Alopecia is the phenomenon of hair falling out. The hair that falls out normally is the hair that is in catagen and resting period, because the hair that enters catagen and the hair that newly enters growth period is constantly in dynamic balance, so can maintain the hair of normal quantity. Pathological alopecia refers to abnormal or excessive shedding of hair. There are many reasons for it, such as excessive stress, lack of sleep, and endocrine disorders. [0003] In recent years, with the development of society and economy, the pace of life has accelerated, work and psychological pressure have increased, lack of sleep, endocrine disorders, and excessive intake of high-fat foods have accelerated the increase in the number of people with hair loss, and they are showing a young...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/63A61Q7/00A61Q5/02A61Q5/12A61K31/56A61P17/14
CPCA61K8/63A61Q7/00A61Q5/02A61Q5/12A61K31/56A61P17/14Y02A50/30
Inventor 戴量亓雪徐祥瑞冯志奇
Owner CHINA PHARM UNIV
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