Information analysis method for treating kidney stone through radix astragali-gold mixture, computer equipment and application

Abstract

The invention belongs to the technical field of network pharmacology and molecular docking, and discloses an information analysis method, computer equipment and application of a Qijin mixture for treating kidney stone, and the information analysis method comprises the following steps: acquiring effective components and disease targets of medicines by utilizing a plurality of databases, and taking intersection genes of the effective components and the disease targets; the method comprises the following steps: constructing a traditional Chinese medicine-component-target regulation and control network by using Cytoscape 3.8.0 software, and introducing an intersection target gene into a String database to construct a PPI network; carrying out topology analysis and GO and KEGG enrichment analysis on the intersection gene; and docking the active ingredients with the core gene molecules, calculating the minimum binding energy, and making a molecular docking model diagram. According to the application disclosed by the invention, the effective components of the astragalus membranaceus and the lysimachia christinae hance are analyzed through network pharmacology, the combination of the effective components of the medicines and a kidney stone target spot is verified by a molecular docking technology, and the potential action mechanism and action target spot of the astragalus membranaceus and the lysimachia christinae hance for treating the kidney stone are predicted; therefore, the radix astragali-gold mixture can be used for treating the kidney stone through a multi-target, multi-channel and multi-component way.

Description

technical field [0001] The invention belongs to the technical field of network pharmacology and molecular docking, and in particular relates to an information analysis method, computer equipment and application of Qijin mixture for treating kidney stones. Background technique [0002] At present, kidney stone is one of the common diseases in urology. Its incidence rate has reached 1% to 20%, showing an increasing trend year by year. After treatment, its recurrence rate exceeds 50%, and the possibility of recurrence is higher in patients with recurrent stones. The surgical treatment is mostly minimally invasive, including extracorporeal shock wave lithotripsy, percutaneous nephrolithotomy, and flexible ureteroscopy. With the continuous maturity of laparoscopic minimally invasive technology, the treatment methods for kidney stones are also increasing, but how to reduce postoperative residual stones and the high recurrence rate of stones is still a hot spot for many scholars. ...

AI Technical Summary

Problems solved by technology

At present, most studies at home and abroad have confirmed the therapeutic effect of Astragalus and Desmodium on urinary stones, but most of them are single-drug studies, and there are few related studies on the combination of the two.

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